Role of Glial Cells in the Functional Expression of LL-37/Rat Cathelin-Related Antimicrobial Peptide in Meningitis

ABSTRACTAntimicrobial peptides are intrinsic to the innate immune system in many organ systems, but little is known about their expression in the central nervous system. We examined cerebrospinal fluid (CSF) and serum from patients with active bacterial meningitis to assess antimicrobial peptides an...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2008-11, Vol.67 (11), p.1041-1054
Hauptverfasser:	Brandenburg, Lars-Ove, Varoga, Deike, Nicolaeva, Nicoletta, Leib, Stephen L, Wilms, Henrik, Podschun, Rainer, Wruck, Christoph J, Schröder, Jens-Michael, Pufe, Thomas, Lucius, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Animals, Newborn Anti-Bacterial Agents - cerebrospinal fluid Anti-Bacterial Agents - therapeutic use Antimicrobial Cationic Peptides - cerebrospinal fluid Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - therapeutic use Biological and medical sciences Brain - cytology Cells, Cultured Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Gene Expression - drug effects Gene Expression - physiology Humans Male Medical sciences Meningitis, Pneumococcal - blood Meningitis, Pneumococcal - cerebrospinal fluid Middle Aged Muramidase - metabolism Neuroglia - drug effects Neuroglia - metabolism Neuroglia - microbiology Neurology Nitrites - metabolism Rats Rats, Wistar RNA, Messenger - metabolism Time Factors Vascular diseases and vascular malformations of the nervous system Young Adult
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