Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys

Increasing evidence suggests a pivotal role for neuroinflammation in the pathogenesis of Parkinson disease, but whether activated microglia participate in disease progression remains unclear. To clarify this issue, we determined the numbers of activated microglial cells in the substantia nigra pars...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2009-09, Vol.68 (9), p.977-984
Hauptverfasser:	Vázquez-Claverie, Marianne, Garrido-Gil, Pablo, San Sebastián, Waldy, Izal-Azcárate, Amaya, Belzunegui, Silvia, Marcilla, Irene, López, Berta, Luquin, María-Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Immunohistochemistry Inflammation - chemically induced Inflammation - immunology Macaca fascicularis Male Medical sciences Microglia - drug effects Microglia - metabolism Microglia - pathology MPTP Poisoning - immunology MPTP Poisoning - metabolism MPTP Poisoning - pathology Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurology Neurons - drug effects Neurons - pathology Neurotoxins - administration & dosage Substantia Nigra - drug effects Substantia Nigra - immunology Substantia Nigra - metabolism
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