Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion

Indomethacin is commonly administered for the prophylaxis of heterotopic ossification (HO) after the surgical treatment of acetabular fractures. Non-steroidal anti-inflammatory drugs such as indomethacin, have been associated with delayed healing of fractures and mechanically weaker callus. Our aim...

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Veröffentlicht in:	Journal of bone and joint surgery. British volume 2003-07, Vol.85 (5), p.700-705
Hauptverfasser:	BURD, T. A, HUGHES, M. S, ANGLEN, J. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetabulum - injuries Adult Aged Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arm Injuries - physiopathology Arm Injuries - surgery Biological and medical sciences Fracture Fixation - methods Fracture Healing - drug effects Fracture Healing - physiology Fractures, Bone - physiopathology Fractures, Bone - radiotherapy Fractures, Bone - surgery Humans Indomethacin - adverse effects Indomethacin - therapeutic use Injuries of the limb. Injuries of the spine Leg Injuries - physiopathology Leg Injuries - surgery Medical sciences Middle Aged Multivariate Analysis Ossification, Heterotopic - prevention & control Postoperative Complications - prevention & control Risk Factors Traumas. Diseases due to physical agents
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