Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging
Long-term tumor hypoxia has always been a huge obstacle for oxygen dependent photodynamic therapy (PDT) and anticancer drug chemotherapy. Herein, a hollow-structured biophotocatalyst was developed by coating mesoporous cerium oxide (mCeO x ) on upconversion nanoparticles (UCNPs, NaGdF 4 :Yb,Tm@NaGdF...
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| Veröffentlicht in: | Chemical science (Cambridge) 2019-09, Vol.1 (37), p.8618-8633 |
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| creator | Jia, Tao Xu, Jiating Dong, Shuming He, Fei Zhong, Chongna Yang, Guixin Bi, Huiting Xu, Mengshu Hu, Yingkui Yang, Dan Yang, Piaoping Lin, Jun |
| description | Long-term tumor hypoxia has always been a huge obstacle for oxygen dependent photodynamic therapy (PDT) and anticancer drug chemotherapy. Herein, a hollow-structured biophotocatalyst was developed by coating mesoporous cerium oxide (mCeO
x
) on upconversion nanoparticles (UCNPs, NaGdF
4
:Yb,Tm@NaGdF
4
), and it can be initialized with a near-infrared (NIR) laser to achieve PDT with O
2
compensation by decomposing the endogenous H
2
O
2
in the tumor microenvironment. A NIR laser with a long wavelength has low phototoxicity to biotissue, and the core-inert shell structured UCNPs can efficiently convert the NIR photons into ultraviolet (UV) light, which can further trigger CeO
x
to produce reactive oxygen species (ROS). Moreover, the internal space of UCNPs@mCeO
x
is ideal for storing chemotherapeutic doxorubicin (DOX), and adequate O
2
plays a key role in alleviating drug fastness
via
chemotherapy in hypoxic tumors, thereby strengthening the synergy between PDT and chemotherapy. After being injected into tumor-bearing mice intravenously, the nanomedicine was able to reach the tumor
via
an enhanced permeability and retention (EPR) effect. In addition, the capability to use the developed nanosystem in computed tomography (CT), magnetic resonance (MR) and upconversion luminescence (UCL) imaging was validated. Significantly, the NIR laser irradiated nanomedicine exhibits an excellent anticancer effect, implying promising theranostic applications.
A hollow structured biophotocatalyst comprising an UCNP core and mesoporous cerium oxide shell was constructed to realize oxygen self-efficient photodynamic therapy upon 980 nm laser irradiation under multiple imaging guidance. |
| doi_str_mv | 10.1039/c9sc01615e |
| format | Article |
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x
) on upconversion nanoparticles (UCNPs, NaGdF
4
:Yb,Tm@NaGdF
4
), and it can be initialized with a near-infrared (NIR) laser to achieve PDT with O
2
compensation by decomposing the endogenous H
2
O
2
in the tumor microenvironment. A NIR laser with a long wavelength has low phototoxicity to biotissue, and the core-inert shell structured UCNPs can efficiently convert the NIR photons into ultraviolet (UV) light, which can further trigger CeO
x
to produce reactive oxygen species (ROS). Moreover, the internal space of UCNPs@mCeO
x
is ideal for storing chemotherapeutic doxorubicin (DOX), and adequate O
2
plays a key role in alleviating drug fastness
via
chemotherapy in hypoxic tumors, thereby strengthening the synergy between PDT and chemotherapy. After being injected into tumor-bearing mice intravenously, the nanomedicine was able to reach the tumor
via
an enhanced permeability and retention (EPR) effect. In addition, the capability to use the developed nanosystem in computed tomography (CT), magnetic resonance (MR) and upconversion luminescence (UCL) imaging was validated. Significantly, the NIR laser irradiated nanomedicine exhibits an excellent anticancer effect, implying promising theranostic applications.
A hollow structured biophotocatalyst comprising an UCNP core and mesoporous cerium oxide shell was constructed to realize oxygen self-efficient photodynamic therapy upon 980 nm laser irradiation under multiple imaging guidance.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/c9sc01615e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Aqueous solutions ; Bearing ; Cancer ; Cerium oxides ; Chemotherapy ; Computed tomography ; Decomposition ; Doxorubicin ; Emission analysis ; Heart ; Hydrogen peroxide ; Hypoxia ; Infrared lasers ; Infrared spectroscopy ; Lasers ; Light irradiation ; Magnetic permeability ; Magnetic resonance ; Medical imaging ; Mice ; Nanoparticles ; Photodynamic therapy ; Photon correlation spectroscopy ; Porosity ; Spectra ; Tumors</subject><ispartof>Chemical science (Cambridge), 2019-09, Vol.1 (37), p.8618-8633</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-31ed484bf5c1809acaeea9c58e11d8a0e66448201c74dc2055cbf678af4c69223</citedby><cites>FETCH-LOGICAL-c358t-31ed484bf5c1809acaeea9c58e11d8a0e66448201c74dc2055cbf678af4c69223</cites><orcidid>0000-0002-9555-1803 ; 0000-0001-9572-2134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Jia, Tao</creatorcontrib><creatorcontrib>Xu, Jiating</creatorcontrib><creatorcontrib>Dong, Shuming</creatorcontrib><creatorcontrib>He, Fei</creatorcontrib><creatorcontrib>Zhong, Chongna</creatorcontrib><creatorcontrib>Yang, Guixin</creatorcontrib><creatorcontrib>Bi, Huiting</creatorcontrib><creatorcontrib>Xu, Mengshu</creatorcontrib><creatorcontrib>Hu, Yingkui</creatorcontrib><creatorcontrib>Yang, Dan</creatorcontrib><creatorcontrib>Yang, Piaoping</creatorcontrib><creatorcontrib>Lin, Jun</creatorcontrib><title>Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging</title><title>Chemical science (Cambridge)</title><description>Long-term tumor hypoxia has always been a huge obstacle for oxygen dependent photodynamic therapy (PDT) and anticancer drug chemotherapy. Herein, a hollow-structured biophotocatalyst was developed by coating mesoporous cerium oxide (mCeO
x
) on upconversion nanoparticles (UCNPs, NaGdF
4
:Yb,Tm@NaGdF
4
), and it can be initialized with a near-infrared (NIR) laser to achieve PDT with O
2
compensation by decomposing the endogenous H
2
O
2
in the tumor microenvironment. A NIR laser with a long wavelength has low phototoxicity to biotissue, and the core-inert shell structured UCNPs can efficiently convert the NIR photons into ultraviolet (UV) light, which can further trigger CeO
x
to produce reactive oxygen species (ROS). Moreover, the internal space of UCNPs@mCeO
x
is ideal for storing chemotherapeutic doxorubicin (DOX), and adequate O
2
plays a key role in alleviating drug fastness
via
chemotherapy in hypoxic tumors, thereby strengthening the synergy between PDT and chemotherapy. After being injected into tumor-bearing mice intravenously, the nanomedicine was able to reach the tumor
via
an enhanced permeability and retention (EPR) effect. In addition, the capability to use the developed nanosystem in computed tomography (CT), magnetic resonance (MR) and upconversion luminescence (UCL) imaging was validated. Significantly, the NIR laser irradiated nanomedicine exhibits an excellent anticancer effect, implying promising theranostic applications.
A hollow structured biophotocatalyst comprising an UCNP core and mesoporous cerium oxide shell was constructed to realize oxygen self-efficient photodynamic therapy upon 980 nm laser irradiation under multiple imaging guidance.</description><subject>Anticancer properties</subject><subject>Aqueous solutions</subject><subject>Bearing</subject><subject>Cancer</subject><subject>Cerium oxides</subject><subject>Chemotherapy</subject><subject>Computed tomography</subject><subject>Decomposition</subject><subject>Doxorubicin</subject><subject>Emission analysis</subject><subject>Heart</subject><subject>Hydrogen peroxide</subject><subject>Hypoxia</subject><subject>Infrared lasers</subject><subject>Infrared spectroscopy</subject><subject>Lasers</subject><subject>Light irradiation</subject><subject>Magnetic permeability</subject><subject>Magnetic resonance</subject><subject>Medical imaging</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Photodynamic therapy</subject><subject>Photon correlation spectroscopy</subject><subject>Porosity</subject><subject>Spectra</subject><subject>Tumors</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpFkE1Lw0AQhoMoWLQX78KCNyG6H9ltcpRSP6DiQT2H7WTSbml24m5S2n9vtFLnMnN4mPflSZIrwe8EV8U9FBG4MELjSTKSPBOp0ao4Pd6SnyfjGNd8GKWElpNRsnvFSC0F6iMDDK5vGO1chSmQ7bBifQvktxiiI8-89dTa0DnYYGQ1Bdb1DYU0YGzJR7dFBitsKG1X1FG197ZxwLoVBtvumfUVWzhyjV06v7xMzmq7iTj-2xfJ5-PsY_qczt-eXqYP8xSUzrtUCayyPFvUGkTOCwsW0RagcxSiyi1HY7Isl1zAJKtAcq1hUZtJbusMTCGlukhuDn_bQF89xq5cUx_8EFlKWRijtdH5QN0eKAgUY8C6bMNQNOxLwcsfueW0eJ_-yp0N8PUBDhGO3L989Q2i63mj</recordid><startdate>20190925</startdate><enddate>20190925</enddate><creator>Jia, Tao</creator><creator>Xu, Jiating</creator><creator>Dong, Shuming</creator><creator>He, Fei</creator><creator>Zhong, Chongna</creator><creator>Yang, Guixin</creator><creator>Bi, Huiting</creator><creator>Xu, Mengshu</creator><creator>Hu, Yingkui</creator><creator>Yang, Dan</creator><creator>Yang, Piaoping</creator><creator>Lin, Jun</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-9555-1803</orcidid><orcidid>https://orcid.org/0000-0001-9572-2134</orcidid></search><sort><creationdate>20190925</creationdate><title>Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging</title><author>Jia, Tao ; Xu, Jiating ; Dong, Shuming ; He, Fei ; Zhong, Chongna ; Yang, Guixin ; Bi, Huiting ; Xu, Mengshu ; Hu, Yingkui ; Yang, Dan ; Yang, Piaoping ; Lin, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-31ed484bf5c1809acaeea9c58e11d8a0e66448201c74dc2055cbf678af4c69223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Aqueous solutions</topic><topic>Bearing</topic><topic>Cancer</topic><topic>Cerium oxides</topic><topic>Chemotherapy</topic><topic>Computed tomography</topic><topic>Decomposition</topic><topic>Doxorubicin</topic><topic>Emission analysis</topic><topic>Heart</topic><topic>Hydrogen peroxide</topic><topic>Hypoxia</topic><topic>Infrared lasers</topic><topic>Infrared spectroscopy</topic><topic>Lasers</topic><topic>Light irradiation</topic><topic>Magnetic permeability</topic><topic>Magnetic resonance</topic><topic>Medical imaging</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Photodynamic therapy</topic><topic>Photon correlation spectroscopy</topic><topic>Porosity</topic><topic>Spectra</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Tao</creatorcontrib><creatorcontrib>Xu, Jiating</creatorcontrib><creatorcontrib>Dong, Shuming</creatorcontrib><creatorcontrib>He, Fei</creatorcontrib><creatorcontrib>Zhong, Chongna</creatorcontrib><creatorcontrib>Yang, Guixin</creatorcontrib><creatorcontrib>Bi, Huiting</creatorcontrib><creatorcontrib>Xu, Mengshu</creatorcontrib><creatorcontrib>Hu, Yingkui</creatorcontrib><creatorcontrib>Yang, Dan</creatorcontrib><creatorcontrib>Yang, Piaoping</creatorcontrib><creatorcontrib>Lin, Jun</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Tao</au><au>Xu, Jiating</au><au>Dong, Shuming</au><au>He, Fei</au><au>Zhong, Chongna</au><au>Yang, Guixin</au><au>Bi, Huiting</au><au>Xu, Mengshu</au><au>Hu, Yingkui</au><au>Yang, Dan</au><au>Yang, Piaoping</au><au>Lin, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging</atitle><jtitle>Chemical science (Cambridge)</jtitle><date>2019-09-25</date><risdate>2019</risdate><volume>1</volume><issue>37</issue><spage>8618</spage><epage>8633</epage><pages>8618-8633</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>Long-term tumor hypoxia has always been a huge obstacle for oxygen dependent photodynamic therapy (PDT) and anticancer drug chemotherapy. Herein, a hollow-structured biophotocatalyst was developed by coating mesoporous cerium oxide (mCeO
x
) on upconversion nanoparticles (UCNPs, NaGdF
4
:Yb,Tm@NaGdF
4
), and it can be initialized with a near-infrared (NIR) laser to achieve PDT with O
2
compensation by decomposing the endogenous H
2
O
2
in the tumor microenvironment. A NIR laser with a long wavelength has low phototoxicity to biotissue, and the core-inert shell structured UCNPs can efficiently convert the NIR photons into ultraviolet (UV) light, which can further trigger CeO
x
to produce reactive oxygen species (ROS). Moreover, the internal space of UCNPs@mCeO
x
is ideal for storing chemotherapeutic doxorubicin (DOX), and adequate O
2
plays a key role in alleviating drug fastness
via
chemotherapy in hypoxic tumors, thereby strengthening the synergy between PDT and chemotherapy. After being injected into tumor-bearing mice intravenously, the nanomedicine was able to reach the tumor
via
an enhanced permeability and retention (EPR) effect. In addition, the capability to use the developed nanosystem in computed tomography (CT), magnetic resonance (MR) and upconversion luminescence (UCL) imaging was validated. Significantly, the NIR laser irradiated nanomedicine exhibits an excellent anticancer effect, implying promising theranostic applications.
A hollow structured biophotocatalyst comprising an UCNP core and mesoporous cerium oxide shell was constructed to realize oxygen self-efficient photodynamic therapy upon 980 nm laser irradiation under multiple imaging guidance.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c9sc01615e</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-9555-1803</orcidid><orcidid>https://orcid.org/0000-0001-9572-2134</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Chemical science (Cambridge), 2019-09, Vol.1 (37), p.8618-8633 |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Anticancer properties Aqueous solutions Bearing Cancer Cerium oxides Chemotherapy Computed tomography Decomposition Doxorubicin Emission analysis Heart Hydrogen peroxide Hypoxia Infrared lasers Infrared spectroscopy Lasers Light irradiation Magnetic permeability Magnetic resonance Medical imaging Mice Nanoparticles Photodynamic therapy Photon correlation spectroscopy Porosity Spectra Tumors |
| title | Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging |
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