Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

1 Center for Biomedicine and Medical Technology Mannheim, Joint Research Division Vascular Biology of the Medical Faculty Mannheim, University of Heidelberg and the German Cancer Research Center, Heidelberg; 2 Medical Faculty Mannheim, Fifth Medical Department, University of Heidelberg, Mannheim; an...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2009-03, Vol.296 (3), p.H893-H899
Hauptverfasser:	Kroll, Jens, Epting, Daniel, Kern, Katrin, Dietz, Christian T, Feng, Yuxi, Hammes, Hans-Peter, Wieland, Thomas, Augustin, Hellmut G
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Angiogenesis Angiogenesis Inducing Agents - pharmacology Angiogenesis Inhibitors - pharmacology Animals Animals, Newborn Cells Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - enzymology Humans Kidneys Kinases Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neovascularization, Physiologic - drug effects Oxygen Phthalazines - pharmacology Physiology Protein Kinase Inhibitors - pharmacology Proteins Pyridines - pharmacology Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor - metabolism Retinal Neovascularization - chemically induced Retinal Neovascularization - enzymology Retinal Neovascularization - physiopathology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - genetics rho-Associated Kinases - metabolism RNA Interference RNA, Small Interfering - metabolism Rodents Signal transduction Vascular Endothelial Growth Factor A - metabolism
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