Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

1 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis; 2 Vascular Biology Center, University of Minnesota Medical School, Minneapolis; 3 Department of Veterinary Population Medicine, University of Minnesota College of Vete...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2009-10, Vol.297 (4), p.H1243-H1253
Hauptverfasser:	Beckman, Joan D, Belcher, John D, Vineyard, Julie V, Chen, Chunsheng, Nguyen, Julia, Nwaneri, M. Osita, O'Sullivan, M. Gerard, Gulbahce, Evin, Hebbel, Robert P, Vercellotti, Gregory M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - genetics Anemia, Sickle Cell - pathology Animals Anti-Inflammatory Agents - administration & dosage Apoferritins - metabolism Bone marrow Carbon Monoxide - administration & dosage Carboxyhemoglobin - metabolism Cells, Cultured Cytokines - blood Dose-Response Relationship, Drug Enzyme Activation Erythroid Precursor Cells - drug effects Female Granulocyte-Macrophage Progenitor Cells - drug effects Hematopoiesis - drug effects Heme Oxygenase-1 - metabolism Hemoglobin, Sickle - genetics Hemoglobin, Sickle - metabolism Hemolysis - drug effects Humans Hypoxia Leukocyte Count Leukocytosis - blood Leukocytosis - drug therapy Leukocytosis - genetics Leukocytosis - pathology Liver - drug effects Liver - metabolism Liver - pathology Lymphocytes Lymphocytes - drug effects Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Necrosis p38 Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rodents Sickle cell disease Time Factors
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