Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium‐Sized Lactones and Lactams

A strategy for the synthesis of medium‐sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high‐dilution conditions usually...

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Veröffentlicht in:Angewandte Chemie 2019-09, Vol.131 (39), p.14080-14085
Hauptverfasser: Lawer, Aggie, Rossi‐Ashton, James A., Stephens, Thomas C., Challis, Bradley J., Epton, Ryan G., Lynam, Jason M., Unsworth, William P.
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Sprache:eng
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