Effects of recombinant eNOS gene expression on reactivity of small cerebral arteries

Resistance arteries are an important target for vascular gene therapy because they play a key role in the regulation of tissue blood flow. The present study was designed to determine the effects of recombinant endothelial (e) nitric oxide synthase (NOS) gene expression on vasomotor reactivity of sma...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-02, Vol.47 (2), p.H420-H427
Hauptverfasser:	TSUTSUI, M, ONOUE, H, IIDA, Y, SMITH, L, O'BRIEN, T, KATUSIC, Z. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Blood vessels Brain Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Enzymes Fundamental and applied biological sciences. Psychology Gene therapy Genes Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Vertebrates: nervous system and sense organs
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Zusammenfassung:	Resistance arteries are an important target for vascular gene therapy because they play a key role in the regulation of tissue blood flow. The present study was designed to determine the effects of recombinant endothelial (e) nitric oxide synthase (NOS) gene expression on vasomotor reactivity of small brain stem arteries (internal diameter, 253 +/- 2.5 mum).
ISSN:	0363-6135 1522-1539