Knockout of Na+/Ca^sup 2+^ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca^sup 2+^ channel current and lowers blood pressure

Mice with smooth muscle (SM)-specific knockout of Na.../Ca... exchanger type-1 (NCX1...) and the NCX inhibitor, SEA0400, were used to study the physiological role of NCX1 in mouse mesenteric arteries. NCX1 protein expression was greatly reduced in arteries from NCX1... mice generated with Cre recomb...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2010-05, Vol.298 (5), p.H1472
Hauptverfasser:	Zhang, Jin, Ren, Chongyu, Chen, Ling, Navedo, Manuel F, Antos, Laura K, Kinsey, Stephen P, Iwamoto, Takahiro, Philipson, D, Kotlikoff, Michael I, Santana, Luis F, Wier, W Gil, Matteson, Donald R, Blaustein, Mordecai P
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood pressure Calcium Mutation Rodents Veins & arteries
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