Correction of hypovolemic hypotension by centrally administered naloxone in conscious rabbits
Our goal was to test directly whether the vasoconstrictor action of naloxone during hypovolemic hypotension is centrally mediated. In eight chronically instrumented rabbits, progressive central hypovolemia and fall in cardiac output (CO) were produced by gradually inflating a cuff on the thoracic ve...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1998-04, Vol.43 (4), p.H1371-H1377 |
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| container_issue | 4 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 43 |
| creator | VAN LEEUWEN, A. F BLAKE, D. W LUDBROOK, J |
| description | Our goal was to test directly whether the vasoconstrictor action of naloxone during hypovolemic hypotension is centrally mediated. In eight chronically instrumented rabbits, progressive central hypovolemia and fall in cardiac output (CO) were produced by gradually inflating a cuff on the thoracic vena cava. Central hypovolemia was then sustained for 8 min by holding CO constant. In the main experiment (n = 4), each rabbit was studied eight times over 4 experimental days. |
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F ; BLAKE, D. W ; LUDBROOK, J</creator><creatorcontrib>VAN LEEUWEN, A. F ; BLAKE, D. W ; LUDBROOK, J</creatorcontrib><description>Our goal was to test directly whether the vasoconstrictor action of naloxone during hypovolemic hypotension is centrally mediated. In eight chronically instrumented rabbits, progressive central hypovolemia and fall in cardiac output (CO) were produced by gradually inflating a cuff on the thoracic vena cava. Central hypovolemia was then sustained for 8 min by holding CO constant. In the main experiment (n = 4), each rabbit was studied eight times over 4 experimental days.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Analgesics ; Biological and medical sciences ; Cardiology ; Circulatory system ; Medical sciences ; Nervous system ; Neuropharmacology ; Pharmacology. Drug treatments ; Rabbits</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1998-04, Vol.43 (4), p.H1371-H1377</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Physiological Society Apr 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2225286$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN LEEUWEN, A. F</creatorcontrib><creatorcontrib>BLAKE, D. W</creatorcontrib><creatorcontrib>LUDBROOK, J</creatorcontrib><title>Correction of hypovolemic hypotension by centrally administered naloxone in conscious rabbits</title><title>American journal of physiology. Heart and circulatory physiology</title><description>Our goal was to test directly whether the vasoconstrictor action of naloxone during hypovolemic hypotension is centrally mediated. In eight chronically instrumented rabbits, progressive central hypovolemia and fall in cardiac output (CO) were produced by gradually inflating a cuff on the thoracic vena cava. Central hypovolemia was then sustained for 8 min by holding CO constant. In the main experiment (n = 4), each rabbit was studied eight times over 4 experimental days.</description><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Circulatory system</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN LEEUWEN, A. F</creatorcontrib><creatorcontrib>BLAKE, D. W</creatorcontrib><creatorcontrib>LUDBROOK, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN LEEUWEN, A. F</au><au>BLAKE, D. 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In the main experiment (n = 4), each rabbit was studied eight times over 4 experimental days.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
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| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1998-04, Vol.43 (4), p.H1371-H1377 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229580212 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Analgesics Biological and medical sciences Cardiology Circulatory system Medical sciences Nervous system Neuropharmacology Pharmacology. Drug treatments Rabbits |
| title | Correction of hypovolemic hypotension by centrally administered naloxone in conscious rabbits |
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