Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography
The Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands Submitted 15 May 2008 ; accepted in final form 19 August 2008 The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2008-10, Vol.295 (4), p.H1705-H1711 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | H1711 |
|---|---|
| container_issue | 4 |
| container_start_page | H1705 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 295 |
| creator | van Dalen, Bas M Soliman, Osama I. I Vletter, Wim B ten Cate, Folkert J Geleijnse, Marcel L |
| description | The Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
Submitted 15 May 2008
; accepted in final form 19 August 2008
The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rot early ), LV peak systolic rotation during ejection (Rot max ), instantaneous LV peak systolic twist (Twist max ), the time to Rot early , Rot max , and Twist max , and rotational deformation delay (defined as the difference of time to basal Rot max and apical Rot max ) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rot max ( P < 0.05), time to apical Rot max ( P < 0.01), and Twist max ( P < 0.01) increased, whereas basal Rot early ( P < 0.001), time to basal Rot early ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twist max ( R 2 = 0.20, P < 0.05). In conclusion, Twist max increased with aging, resulting from both increased apical Rot max and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.
aging; left ventricular function
Address for reprint requests and other correspondence: M. L. Geleijnse, Erasmus Univ. Medical Center, The Thoraxcenter, Rm. BA 302, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands (e-mail: m.geleijnse{at}erasmusmc.nl ) |
| doi_str_mv | 10.1152/ajpheart.00513.2008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_229573606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69642387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-4c8dde1114ce080c8d6eb8f20d338b3e2dce1b8e9cc1778818843bd5c8bd1f2a3</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoModm39BYIEL7ybbT7mI4tXpVgrFLxpr0MmOTOTbWYyJpnW_fdm3bVKoVchyfMcXs6L0AdK1pRW7Fxt5wFUSGtCKsrXjBDxCq3yDytoxTev0Yrwmhc15dUJehfjlmSwqflbdEJFw3hTNyvkL3ooAjiVwGA9qKmHiO2E0wC4tX6E_ZvVEfsOO-gSfoApBasXpwJOjzYmPIKKS8h6u8NxBn3vAKeg9L2depx9r1Uw1vdBzcPuDL3plIvw_nieorurr7eX18XNj2_fLy9uCl0KkYpSC2OAUlpqIILkWw2t6BgxnIuWAzMaaCtgozVtGiGoECVvTaVFa2jHFD9Fnw9z5-B_LhCTHG3U4JyawC9R1pu6ZFw0Gfz0DNz6JUw5m2RsUzW8JnWG-AHSwccYoJNzsKMKO0mJ3Jch_5Yh_5Qh92Vk6-Nx9NKOYP45x-1n4MsBGGw_PNoAMm8oWu98v5NXi3O38Cs9jc5pZCmvaUMqOZsu2-cv2095_rP4b_s6sDE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229573606</pqid></control><display><type>article</type><title>Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography</title><source>MEDLINE</source><source>American Physiological Society Paid</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>van Dalen, Bas M ; Soliman, Osama I. I ; Vletter, Wim B ; ten Cate, Folkert J ; Geleijnse, Marcel L</creator><creatorcontrib>van Dalen, Bas M ; Soliman, Osama I. I ; Vletter, Wim B ; ten Cate, Folkert J ; Geleijnse, Marcel L</creatorcontrib><description><![CDATA[The Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
Submitted 15 May 2008
; accepted in final form 19 August 2008
The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rot early ), LV peak systolic rotation during ejection (Rot max ), instantaneous LV peak systolic twist (Twist max ), the time to Rot early , Rot max , and Twist max , and rotational deformation delay (defined as the difference of time to basal Rot max and apical Rot max ) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rot max ( P < 0.05), time to apical Rot max ( P < 0.01), and Twist max ( P < 0.01) increased, whereas basal Rot early ( P < 0.001), time to basal Rot early ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twist max ( R 2 = 0.20, P < 0.05). In conclusion, Twist max increased with aging, resulting from both increased apical Rot max and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.
aging; left ventricular function
Address for reprint requests and other correspondence: M. L. Geleijnse, Erasmus Univ. Medical Center, The Thoraxcenter, Rm. BA 302, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands (e-mail: m.geleijnse{at}erasmusmc.nl )]]></description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00513.2008</identifier><identifier>PMID: 18723767</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aging ; Correlation analysis ; Echocardiography - methods ; Electrocardiography ; Feasibility Studies ; Female ; Heart ; Heart Ventricles - diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Myocardial Contraction ; Older people ; Rotation ; Stroke Volume ; Studies ; Time Factors ; Torsion, Mechanical ; Ultrasonic imaging ; Ventricular Function, Left - physiology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2008-10, Vol.295 (4), p.H1705-H1711</ispartof><rights>Copyright American Physiological Society Oct 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-4c8dde1114ce080c8d6eb8f20d338b3e2dce1b8e9cc1778818843bd5c8bd1f2a3</citedby><cites>FETCH-LOGICAL-c488t-4c8dde1114ce080c8d6eb8f20d338b3e2dce1b8e9cc1778818843bd5c8bd1f2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18723767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Dalen, Bas M</creatorcontrib><creatorcontrib>Soliman, Osama I. I</creatorcontrib><creatorcontrib>Vletter, Wim B</creatorcontrib><creatorcontrib>ten Cate, Folkert J</creatorcontrib><creatorcontrib>Geleijnse, Marcel L</creatorcontrib><title>Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description><![CDATA[The Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
Submitted 15 May 2008
; accepted in final form 19 August 2008
The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rot early ), LV peak systolic rotation during ejection (Rot max ), instantaneous LV peak systolic twist (Twist max ), the time to Rot early , Rot max , and Twist max , and rotational deformation delay (defined as the difference of time to basal Rot max and apical Rot max ) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rot max ( P < 0.05), time to apical Rot max ( P < 0.01), and Twist max ( P < 0.01) increased, whereas basal Rot early ( P < 0.001), time to basal Rot early ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twist max ( R 2 = 0.20, P < 0.05). In conclusion, Twist max increased with aging, resulting from both increased apical Rot max and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.
aging; left ventricular function
Address for reprint requests and other correspondence: M. L. Geleijnse, Erasmus Univ. Medical Center, The Thoraxcenter, Rm. BA 302, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands (e-mail: m.geleijnse{at}erasmusmc.nl )]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Correlation analysis</subject><subject>Echocardiography - methods</subject><subject>Electrocardiography</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction</subject><subject>Older people</subject><subject>Rotation</subject><subject>Stroke Volume</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Torsion, Mechanical</subject><subject>Ultrasonic imaging</subject><subject>Ventricular Function, Left - physiology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEUhoModm39BYIEL7ybbT7mI4tXpVgrFLxpr0MmOTOTbWYyJpnW_fdm3bVKoVchyfMcXs6L0AdK1pRW7Fxt5wFUSGtCKsrXjBDxCq3yDytoxTev0Yrwmhc15dUJehfjlmSwqflbdEJFw3hTNyvkL3ooAjiVwGA9qKmHiO2E0wC4tX6E_ZvVEfsOO-gSfoApBasXpwJOjzYmPIKKS8h6u8NxBn3vAKeg9L2depx9r1Uw1vdBzcPuDL3plIvw_nieorurr7eX18XNj2_fLy9uCl0KkYpSC2OAUlpqIILkWw2t6BgxnIuWAzMaaCtgozVtGiGoECVvTaVFa2jHFD9Fnw9z5-B_LhCTHG3U4JyawC9R1pu6ZFw0Gfz0DNz6JUw5m2RsUzW8JnWG-AHSwccYoJNzsKMKO0mJ3Jch_5Yh_5Qh92Vk6-Nx9NKOYP45x-1n4MsBGGw_PNoAMm8oWu98v5NXi3O38Cs9jc5pZCmvaUMqOZsu2-cv2095_rP4b_s6sDE</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>van Dalen, Bas M</creator><creator>Soliman, Osama I. I</creator><creator>Vletter, Wim B</creator><creator>ten Cate, Folkert J</creator><creator>Geleijnse, Marcel L</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography</title><author>van Dalen, Bas M ; Soliman, Osama I. I ; Vletter, Wim B ; ten Cate, Folkert J ; Geleijnse, Marcel L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-4c8dde1114ce080c8d6eb8f20d338b3e2dce1b8e9cc1778818843bd5c8bd1f2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aging</topic><topic>Correlation analysis</topic><topic>Echocardiography - methods</topic><topic>Electrocardiography</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction</topic><topic>Older people</topic><topic>Rotation</topic><topic>Stroke Volume</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Torsion, Mechanical</topic><topic>Ultrasonic imaging</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Dalen, Bas M</creatorcontrib><creatorcontrib>Soliman, Osama I. I</creatorcontrib><creatorcontrib>Vletter, Wim B</creatorcontrib><creatorcontrib>ten Cate, Folkert J</creatorcontrib><creatorcontrib>Geleijnse, Marcel L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Dalen, Bas M</au><au>Soliman, Osama I. I</au><au>Vletter, Wim B</au><au>ten Cate, Folkert J</au><au>Geleijnse, Marcel L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>295</volume><issue>4</issue><spage>H1705</spage><epage>H1711</epage><pages>H1705-H1711</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract><![CDATA[The Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
Submitted 15 May 2008
; accepted in final form 19 August 2008
The increasing number and proportion of aged individuals in the population warrants knowledge of normal physiological changes of left ventricular (LV) biomechanics with advancing age. LV twist describes the instantaneous circumferential motion of the apex with respect to the base of the heart and has an important role in LV ejection and filling. This study sought to investigate the biomechanics behind age-related changes in LV twist by determining a broad spectrum of LV rotation parameters in different age groups, using speckle tracking echocardiography (STE). The final study population consisted of 61 healthy volunteers (16–35 yr, n = 25; 36–55 yr, n = 23; 56–75 yr, n = 13; 31 men). LV peak systolic rotation during the isovolumic contraction phase (Rot early ), LV peak systolic rotation during ejection (Rot max ), instantaneous LV peak systolic twist (Twist max ), the time to Rot early , Rot max , and Twist max , and rotational deformation delay (defined as the difference of time to basal Rot max and apical Rot max ) were determined by STE using QLAB Advanced Quantification Software (version 6.0; Philips, Best, The Netherlands). With increasing age, apical Rot max ( P < 0.05), time to apical Rot max ( P < 0.01), and Twist max ( P < 0.01) increased, whereas basal Rot early ( P < 0.001), time to basal Rot early ( P < 0.01), and rotational deformation delay ( P < 0.05) decreased. Rotational deformation delay was significantly correlated to Twist max ( R 2 = 0.20, P < 0.05). In conclusion, Twist max increased with aging, resulting from both increased apical Rot max and decreased rotational deformation delay between the apex and the base of the LV. This may explain the preservation of LV ejection fraction in the elderly.
aging; left ventricular function
Address for reprint requests and other correspondence: M. L. Geleijnse, Erasmus Univ. Medical Center, The Thoraxcenter, Rm. BA 302, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands (e-mail: m.geleijnse{at}erasmusmc.nl )]]></abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>18723767</pmid><doi>10.1152/ajpheart.00513.2008</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2008-10, Vol.295 (4), p.H1705-H1711 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229573606 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Age Distribution Age Factors Aged Aging Correlation analysis Echocardiography - methods Electrocardiography Feasibility Studies Female Heart Heart Ventricles - diagnostic imaging Humans Image Interpretation, Computer-Assisted Male Middle Aged Myocardial Contraction Older people Rotation Stroke Volume Studies Time Factors Torsion, Mechanical Ultrasonic imaging Ventricular Function, Left - physiology |
| title | Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A55%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20changes%20in%20the%20biomechanics%20of%20left%20ventricular%20twist%20measured%20by%20speckle%20tracking%20echocardiography&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=van%20Dalen,%20Bas%20M&rft.date=2008-10-01&rft.volume=295&rft.issue=4&rft.spage=H1705&rft.epage=H1711&rft.pages=H1705-H1711&rft.issn=0363-6135&rft.eissn=1522-1539&rft.coden=AJPPDI&rft_id=info:doi/10.1152/ajpheart.00513.2008&rft_dat=%3Cproquest_cross%3E69642387%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229573606&rft_id=info:pmid/18723767&rfr_iscdi=true |