Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice

The loss of dystrophin in patients with Duchenne muscular dystrophy (DMD) causes devastating skeletal muscle degeneration and cardiomyopathy. Dystrophin-deficient (mdx) mice have a much milder phenotype, whereas double knockout (DKO) mice lacking both dystrophin and its homolog, utrophin, exhibit th...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2005-12, Vol.58 (6), p.H2373-H2378
Hauptverfasser:	JANSSEN, Paul M. L, HIRANANDANI, Nitisha, MAYS, Tessily A, RAFAEL-FORTNEY, Jill A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Heart Muscular dystrophy Rodents Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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