Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats
CGRP and substance P (SP) are produced in dorsal root ganglia (DRG) sensory neurons and modulate vascular tone. Sympathetic and sensory nerves compete for NGF, a potent stimulator of CGRP and SP, and it has been suggested that sympathetic hyperinnervation in spontaneously hypertensive rats may reduc...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2005-09, Vol.58 (3), p.H1169-H1175 |
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| container_end_page | H1175 |
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| container_issue | 3 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 58 |
| creator | SUPOWIT, S. C ETHRIDGE, R. T ZHAO, H KATKI, K. A DIPETTE, D. J |
| description | CGRP and substance P (SP) are produced in dorsal root ganglia (DRG) sensory neurons and modulate vascular tone. Sympathetic and sensory nerves compete for NGF, a potent stimulator of CGRP and SP, and it has been suggested that sympathetic hyperinnervation in spontaneously hypertensive rats may reduce the availability of NGF to sensory nerves, thus reducing CGRP and SP. The purpose of this study was to determine whether destruction of peripheral sympathetic nerves in normal rats would increase the availability of NGF for sensory neurons and enhance expression of CGRP and SP. Sympathectomy was produced in rats by guanethidine sulfate administration. Control rats received saline. Sympathectomized rats displayed reductions in blood pressure (BP) and atria norepinephrine levels, whereas NGF levels in the DRG, spleen, and ventricles were increased. Sympathectomy also enhanced CGRP and SP mRNA and peptide content in DRG. Administration of CGRP and SP receptor antagonists increased the BP in sympathectomized rats but not in the controls. Thus sympathectomy enhances sensory neuron CGRP and SP expression that contributes to the BP reduction. [PUBLICATION ABSTRACT] |
| format | Article |
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C ; ETHRIDGE, R. T ; ZHAO, H ; KATKI, K. A ; DIPETTE, D. J</creator><creatorcontrib>SUPOWIT, S. C ; ETHRIDGE, R. T ; ZHAO, H ; KATKI, K. A ; DIPETTE, D. J</creatorcontrib><description>CGRP and substance P (SP) are produced in dorsal root ganglia (DRG) sensory neurons and modulate vascular tone. Sympathetic and sensory nerves compete for NGF, a potent stimulator of CGRP and SP, and it has been suggested that sympathetic hyperinnervation in spontaneously hypertensive rats may reduce the availability of NGF to sensory nerves, thus reducing CGRP and SP. The purpose of this study was to determine whether destruction of peripheral sympathetic nerves in normal rats would increase the availability of NGF for sensory neurons and enhance expression of CGRP and SP. Sympathectomy was produced in rats by guanethidine sulfate administration. Control rats received saline. Sympathectomized rats displayed reductions in blood pressure (BP) and atria norepinephrine levels, whereas NGF levels in the DRG, spleen, and ventricles were increased. Sympathectomy also enhanced CGRP and SP mRNA and peptide content in DRG. Administration of CGRP and SP receptor antagonists increased the BP in sympathectomized rats but not in the controls. Thus sympathectomy enhances sensory neuron CGRP and SP expression that contributes to the BP reduction. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biological and medical sciences ; Blood pressure ; Fundamental and applied biological sciences. Psychology ; Nervous system ; Peptides ; Rodents ; Vertebrates: cardiovascular system</subject><ispartof>American journal of physiology. 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Sympathectomized rats displayed reductions in blood pressure (BP) and atria norepinephrine levels, whereas NGF levels in the DRG, spleen, and ventricles were increased. Sympathectomy also enhanced CGRP and SP mRNA and peptide content in DRG. Administration of CGRP and SP receptor antagonists increased the BP in sympathectomized rats but not in the controls. Thus sympathectomy enhances sensory neuron CGRP and SP expression that contributes to the BP reduction. [PUBLICATION ABSTRACT]</description><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Fundamental and applied biological sciences. 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Sympathetic and sensory nerves compete for NGF, a potent stimulator of CGRP and SP, and it has been suggested that sympathetic hyperinnervation in spontaneously hypertensive rats may reduce the availability of NGF to sensory nerves, thus reducing CGRP and SP. The purpose of this study was to determine whether destruction of peripheral sympathetic nerves in normal rats would increase the availability of NGF for sensory neurons and enhance expression of CGRP and SP. Sympathectomy was produced in rats by guanethidine sulfate administration. Control rats received saline. Sympathectomized rats displayed reductions in blood pressure (BP) and atria norepinephrine levels, whereas NGF levels in the DRG, spleen, and ventricles were increased. Sympathectomy also enhanced CGRP and SP mRNA and peptide content in DRG. Administration of CGRP and SP receptor antagonists increased the BP in sympathectomized rats but not in the controls. 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| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2005-09, Vol.58 (3), p.H1169-H1175 |
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| language | eng |
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| source | American Physiological Society Paid; EZB Electronic Journals Library |
| subjects | Biological and medical sciences Blood pressure Fundamental and applied biological sciences. Psychology Nervous system Peptides Rodents Vertebrates: cardiovascular system |
| title | Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats |
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