MK-801 does not prevent impaired cerebrovascular reactivity to CO(2) during hypoglycemia in piglets

MK-801 does not prevent impaired cerebrovascular reactivity to CO(2) during hypoglycemia in piglets

The hypothesis that severe insulin-induced hypoglycemia would depress cerebrovascular reactivity to CO2 via a mechanism that could be prevented by administration of the N-methyl-D-aspartate receptor antagonist MK-801 was tested in infant piglets.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1993-06, Vol.33 (6), p.H2124
Hauptverfasser: St Jacques, Paul J, Kirsch, Jeffrey R, Diringer, Michael N, Traystman, Richard J
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Brain
Carbon dioxide
Hogs
Hypoglycemia
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Beschreibung
Zusammenfassung:The hypothesis that severe insulin-induced hypoglycemia would depress cerebrovascular reactivity to CO2 via a mechanism that could be prevented by administration of the N-methyl-D-aspartate receptor antagonist MK-801 was tested in infant piglets.
ISSN:0363-6135
1522-1539