Phosphine‐Catalyzed β‐Selective Conjugate Addition of α‐Fluoro‐β‐ketoamides to Allenic Esters

A Strategy for the β‐selective conjugate addition of α‐fluoro‐β‐ketoamides to allenic esters has been developed via phosphine catalysis. This protocol exhibits a broad substrate scope, and a wide range of compounds bearing fluorinated quaternary carbon center was obtained in good to excellent yields...

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Veröffentlicht in:	European journal of organic chemistry 2019-09, Vol.2019 (35), p.6138-6142
Hauptverfasser:	Vaishanv, Narendra Kumar, Zaheer, Mohd Khalid, Kant, Ruchir, Mohanan, Kishor
Format:	Artikel
Sprache:	eng
Schlagworte:	Allenic esters Catalysis Conjugate addition Conjugates Esters Fluorination Homogeneous catalysis Selectivity Substrates Synthesis design α‐Fluoro‐β‐ketoamides
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