Unified Total Synthesis of Hetiamacins A–D

A concise enantioselective total synthesis of hetiamacin A has been accomplished from a known l‐aspartic acid derivative by an eight‐step sequence that features ammonolytic opening of the γ‐lactone moiety of amicoumacin C followed by 1,3‐oxazinane ring formation in one pot. Hetiamacins B–D with puta...

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Veröffentlicht in:	European journal of organic chemistry 2019-09, Vol.2019 (35), p.6110-6116
Hauptverfasser:	Tsukaguchi, Shogo, Enomoto, Masaru, Towada, Ryo, Ogura, Yusuke, Kuwahara, Shigefumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Aspartic acid Enantiomers Hetiamacin Natural products Nitrogen heterocycles NMR Nuclear magnetic resonance Synthesis Total synthesis
Online-Zugang:	Volltext
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