Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer

Endometrial cancer (EC) is one of the most common gynecologic malignancies. However, the molecular mechanisms underlying the development and progression of EC remain unclear. Here, we demonstrated that the protein proviral insertion in murine lymphomas 2 (PIM2) was necessary for maintaining EC tumor...

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Veröffentlicht in:	Oncogene 2019-09, Vol.38 (38), p.6537-6549
Hauptverfasser:	Han, Xue, Ren, Chune, Yang, Tingting, Qiao, Pengyun, Wang, Li, Jiang, Aifang, Meng, Yuhan, Liu, Zhijun, Du, Yu, Yu, Zhenhai
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/95 14/19 631/67/1517/1931 631/80/458/1733 82/29 82/51 82/80 82/83 Adult Aged AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Apoptosis Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell Biology Cell Line, Tumor Cell Proliferation - genetics Down-Regulation - genetics Endometrial cancer Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium Female Glycolysis Glycolysis - genetics HEK293 Cells Human Genetics Humans Internal Medicine Kinases Lymphoma Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Middle Aged Molecular modelling Oncology Phosphorylation Phosphorylation - genetics Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Tumorigenesis
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