Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies
Covering: up to 2019 Humanity is in dire need for novel medicinal compounds with biological activities ranging from antibiotic to anticancer and anti-dementia effects. Recent developments in genome sequencing and mining have revealed an unappreciated potential for bioactive molecule production in ma...
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| Veröffentlicht in: | Natural product reports 2019-09, Vol.36 (9), p.1333-135 |
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| creator | Buijs, Yannick Bech, Pernille Kjersgaard Vazquez-Albacete, Dario Bentzon-Tilia, Mikkel Sonnenschein, Eva C Gram, Lone Zhang, Sheng-Da |
| description | Covering: up to 2019
Humanity is in dire need for novel medicinal compounds with biological activities ranging from antibiotic to anticancer and anti-dementia effects. Recent developments in genome sequencing and mining have revealed an unappreciated potential for bioactive molecule production in marine Proteobacteria. Also, novel bioactive compounds have been discovered through molecular manipulations of either the original marine host bacteria or in heterologous hosts. Nevertheless, in contrast to the large repertoire of such molecules as predicted by
in silico
analysis, few marine bioactive compounds have been reported. This review summarizes the recent advances in the study of natural products from marine Proteobacteria. Here we present successful examples on genetic engineering of biosynthetic gene clusters of natural products from marine Proteobacteria. We also discuss the future prospects of discovering novel bioactive molecules
via
both heterologous production methodology and the development of marine Proteobacteria as new cell factories.
This review covers the recent advances in molecular tools and strategies for studies and use of natural products from marine Proteobacteria. |
| doi_str_mv | 10.1039/c9np00020h |
| format | Article |
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Humanity is in dire need for novel medicinal compounds with biological activities ranging from antibiotic to anticancer and anti-dementia effects. Recent developments in genome sequencing and mining have revealed an unappreciated potential for bioactive molecule production in marine Proteobacteria. Also, novel bioactive compounds have been discovered through molecular manipulations of either the original marine host bacteria or in heterologous hosts. Nevertheless, in contrast to the large repertoire of such molecules as predicted by
in silico
analysis, few marine bioactive compounds have been reported. This review summarizes the recent advances in the study of natural products from marine Proteobacteria. Here we present successful examples on genetic engineering of biosynthetic gene clusters of natural products from marine Proteobacteria. We also discuss the future prospects of discovering novel bioactive molecules
via
both heterologous production methodology and the development of marine Proteobacteria as new cell factories.
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Humanity is in dire need for novel medicinal compounds with biological activities ranging from antibiotic to anticancer and anti-dementia effects. Recent developments in genome sequencing and mining have revealed an unappreciated potential for bioactive molecule production in marine Proteobacteria. Also, novel bioactive compounds have been discovered through molecular manipulations of either the original marine host bacteria or in heterologous hosts. Nevertheless, in contrast to the large repertoire of such molecules as predicted by
in silico
analysis, few marine bioactive compounds have been reported. This review summarizes the recent advances in the study of natural products from marine Proteobacteria. Here we present successful examples on genetic engineering of biosynthetic gene clusters of natural products from marine Proteobacteria. We also discuss the future prospects of discovering novel bioactive molecules
via
both heterologous production methodology and the development of marine Proteobacteria as new cell factories.
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Humanity is in dire need for novel medicinal compounds with biological activities ranging from antibiotic to anticancer and anti-dementia effects. Recent developments in genome sequencing and mining have revealed an unappreciated potential for bioactive molecule production in marine Proteobacteria. Also, novel bioactive compounds have been discovered through molecular manipulations of either the original marine host bacteria or in heterologous hosts. Nevertheless, in contrast to the large repertoire of such molecules as predicted by
in silico
analysis, few marine bioactive compounds have been reported. This review summarizes the recent advances in the study of natural products from marine Proteobacteria. Here we present successful examples on genetic engineering of biosynthetic gene clusters of natural products from marine Proteobacteria. We also discuss the future prospects of discovering novel bioactive molecules
via
both heterologous production methodology and the development of marine Proteobacteria as new cell factories.
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Antibiotics Anticancer properties Bioactive compounds Biological activity Dementia disorders Gene clusters Gene sequencing Genetic engineering Genomes Industrial engineering Manufacturing engineering Marine engineering Natural products Proteobacteria |
| title | Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies |
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