miRNA biomarkers of NSCLC in TNM stage
In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer...
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| Veröffentlicht in: | Thoracic cancer 2016-05, Vol.7 (3), p.348-354 |
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| creator | Pu, Qiang Huang, Yuchuan Lu, Yanrong Peng, Yong Zhang, Jie Feng, Guanglin Wang, Changguo Liu, Lunxu Dai, Ya |
| description | In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking‐related lung fibrosis. Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC. |
| doi_str_mv | 10.1111/1759-7714.12317 |
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Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.</description><identifier>ISSN: 1759-7706</identifier><identifier>EISSN: 1759-7714</identifier><identifier>DOI: 10.1111/1759-7714.12317</identifier><language>eng</language><publisher>Tianjin: John Wiley & Sons, Inc</publisher><subject>Biomarkers ; Blood ; Cancer therapies ; Family medical history ; Gender ; Gene expression ; Hybridization ; Labeling ; Lung cancer ; Manufacturers ; Medical prognosis ; Medical screening ; MicroRNAs ; Patients ; Plasma ; Software ; Statistical analysis ; Studies ; Thoracic surgery ; Tuberculosis</subject><ispartof>Thoracic cancer, 2016-05, Vol.7 (3), p.348-354</ispartof><rights>2016. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). 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Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.</description><subject>Biomarkers</subject><subject>Blood</subject><subject>Cancer therapies</subject><subject>Family medical history</subject><subject>Gender</subject><subject>Gene expression</subject><subject>Hybridization</subject><subject>Labeling</subject><subject>Lung cancer</subject><subject>Manufacturers</subject><subject>Medical prognosis</subject><subject>Medical screening</subject><subject>MicroRNAs</subject><subject>Patients</subject><subject>Plasma</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Thoracic surgery</subject><subject>Tuberculosis</subject><issn>1759-7706</issn><issn>1759-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpjYBA3NNAzBAJ9Q3NTS11zc0MTPUMjY0NzJgZOuAgLnG1gxsHAW1ycZQAExhaWBkamnAxquZlBfo4KSZn5uYlF2alFxQr5aQp-wc4-zgqZeQohfr4KxSWJ6ak8DKxpiTnFqbxQmptB2c01xNlDt6Aov7A0tbgkPiu_tCgPKBVvZGRpYGpuZmRoaUycKgAkIzRV</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Pu, Qiang</creator><creator>Huang, Yuchuan</creator><creator>Lu, Yanrong</creator><creator>Peng, Yong</creator><creator>Zhang, Jie</creator><creator>Feng, Guanglin</creator><creator>Wang, Changguo</creator><creator>Liu, Lunxu</creator><creator>Dai, Ya</creator><general>John Wiley & Sons, Inc</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160501</creationdate><title>miRNA biomarkers of NSCLC in TNM stage</title><author>Pu, Qiang ; 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Herein, we determine whether tissue‐specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non‐small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue‐specific and plasma miR‐211‐3p, miR‐3679‐3p, and miR‐4787‐5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR‐3613‐3p, miR‐3675‐3p, and miR‐5571‐5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue‐specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.</abstract><cop>Tianjin</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1111/1759-7714.12317</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Biomarkers Blood Cancer therapies Family medical history Gender Gene expression Hybridization Labeling Lung cancer Manufacturers Medical prognosis Medical screening MicroRNAs Patients Plasma Software Statistical analysis Studies Thoracic surgery Tuberculosis |
| title | miRNA biomarkers of NSCLC in TNM stage |
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