HDAC 4/5‐ HMGB 1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury

Histone deacetylases ( HDAC s)‐mediated epigenetic mechanisms play critical roles in the homeostasis of histone acetylation and gene transcription. HDAC inhibitors have displayed neuroprotective properties in animal models for various neurological diseases including Alzheimer's disease and isch...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2013-04, Vol.17 (4), p.531-542
Hauptverfasser:	He, Min, Zhang, Bin, Wei, Xinbing, Wang, Ziying, Fan, Baoxia, Du, Pengchao, Zhang, Yan, Jian, Wencheng, Chen, Lin, Wang, Linlin, Fang, Hao, Li, Xiang, Wang, Ping‐An, Yi, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Alzheimer's disease Animal models Apoptosis Brain research Cell viability Cerebral blood flow DNA methylation Epigenetics HDAC protein Histone deacetylase Histones HMGB1 protein Homeostasis Inhibition Inhibitors Ischemia Laboratory animals NAD(P)H oxidase Neurodegenerative diseases Neurological diseases Neuroprotection Neurosciences Oxidative stress Pheochromocytoma cells Proteins R&D Reperfusion Research & development Signal transduction Stroke Studies Transcription Viability Zinc
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