Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

Organic anion transporters (OATs) 1 and 3 are, besides being uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are largely unknown. Hence, we used human conditionally immortalized proximal tubule epithelial cells (ciPTEC) overexpressing OAT1 or OAT3 to gain i...

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Veröffentlicht in:	Biological chemistry 2019-09, Vol.400 (10), p.1347-1358
Hauptverfasser:	Vriend, Jelle, Hoogstraten, Charlotte A., Venrooij, Kevin R., van den Berge, Bartholomeus T., Govers, Larissa P., van Rooij, Arno, Huigen, Marleen C.D.G., Schirris, Tom J.J., Russel, Frans G.M., Masereeuw, Rosalinde, Wilmer, Martijn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions cellular energy metabolism Clear cell-type renal cell carcinoma Depth profiling Efflux Energy Metabolism Epithelial cells HEK293 Cells Humans Intermediates Ketoglutaric acid Ketoglutaric Acids - metabolism Kidney Tubules, Proximal - metabolism Lactic acid Metabolic pathways Metabolism Metabolites Metabolomics Mitochondria OAT1 OAT3 Oats Organic Anion Transport Protein 1 - metabolism Organic Anion Transporters, Sodium-Independent - metabolism Oxidative phosphorylation Phenotypes Phosphorylation renal proximal tubule epithelial cells Respiration Sodium TCA cycle Tricarboxylic acid cycle α-ketoglutarate
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