Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules

Many widespread and persistent organic pollutants, for example, 2,3,7,8-tetrachlorodibenzo- -dioxin (TCDD) and some polychlorinated biphenyls, activate the aryl hydrocarbon receptor (AhR) causing it to translocate to the cell nucleus where it transactivates target genes, increasing expression of a n...

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Veröffentlicht in:	Biological chemistry 2019-09, Vol.400 (10), p.1335-1345
Hauptverfasser:	Mahringer, Anne, Bernd, Alexandra, Miller, David S., Fricker, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Actinomycin Animals Aromatic compounds ATP-Binding Cassette Transporters - metabolism Bcrp beta-Naphthoflavone - pharmacology Breast cancer Cycloheximide Cycloheximide - pharmacology Dactinomycin - pharmacology Dioxins Efflux Excretion Fundulidae Fundulus heteroclitus Gene expression Glycoproteins Hydrocarbons Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Kidneys Ligands MRP protein Mrp2 Mrp4 Multidrug resistance Naphthoflavone Nuclei (cytology) P-Glycoprotein PCB PCB compounds Persistent organic pollutants Pollutants Polychlorinated biphenyls Polychlorinated Dibenzodioxins - pharmacology Protein transport Proteins Proximal tubules Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - metabolism Renal function Renal tubules TCDD Transcription transcriptional regulation Transport
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