BMP ‐9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK 1 mediated pathway

The process of vascular calcification shares many similarities with that of physiological skeletal mineralization, and involves the deposition of hydroxyapatite crystals in arteries. However, the cellular mechanisms responsible have yet to be fully explained. Bone morphogenetic protein ( BMP ‐9) has...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-01, Vol.19 (1), p.165-174
Hauptverfasser:	Zhu, Dongxing, Mackenzie, Neil Charles Wallace, Shanahan, Catherine M., Shroff, Rukshana C., Farquharson, Colin, MacRae, Vicky Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Arteries Bone morphogenetic proteins Calcification Calcification (ectopic) Calcium Crystals Dialysis Gene expression Hemodialysis Hydroxyapatite Immunoglobulins Kidney diseases Kinases Laboratory animals Mineralization Muscles Osteoblastogenesis Osteoblasts Phosphorylation Physiology Proteins R&D Research & development Signal transduction siRNA Smad protein Smad2 protein Smad3 protein Smad4 protein Smooth muscle Studies Transfection
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