New Pyridopyrimidone Derivatives: Synthesis, Molecular Docking Studies, and Potential Anticancer Activity

A new series of pyrido[2,3- d ]pyrimidones incorporated pyrazoles and fused triazoles are synthesized and tested in vitro for cytotoxic effect against cancer cell lines: HePG-2, HCT-116, MCF-7, PC-3, and A-549. Their inhibition of protein kinase is assessed. The highest growth inhibitory (IC 50 0.3...

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Veröffentlicht in:	Russian journal of general chemistry 2019-08, Vol.89 (8), p.1683-1690
Hauptverfasser:	Khalifa, N. M., Alkahtani, H. M., Al-Omar, M. A., Bakheit, A. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antimitotic agents Antineoplastic agents Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Doxorubicin Kinases Molecular docking Protein kinases Triazoles
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