Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database
Background Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative man...
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| Veröffentlicht in: | Cancer 2019-10, Vol.125 (19), p.3338-3346 |
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| creator | Mahal, Amandeep R. Butler, Santino Franco, Idalid Muralidhar, Vinayak Larios, Dalia Pike, Luke R. G. Zhao, Shuang G. Sanford, Nina N. Dess, Robert T. Feng, Felix Y. D’Amico, Anthony V. Spratt, Daniel E. Yu, James B. Nguyen, Paul L. Rebbeck, Timothy R. Mahal, Brandon A. |
| description | Background
Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative management for LRPC and associated short‐term outcomes in young versus older men in the United States.
Methods
The nonpublic Surveillance, Epidemiology, and End Results Prostate with Active Surveillance/Watchful Waiting (AS/WW) Database identified 50,302 men who were diagnosed with LRPC from 2010 through 2015. AS/WW rates in the United States were stratified by age (≤55 vs ≥56 years). Prostate cancer‐specific mortality and overall mortality were defined by initial management type (AS/WW vs definitive treatment [referent]) and age.
Results
AS/WW utilization increased from 8.61% (2010) to 34.56% (2015) among men aged ≤55 years (P for trend |
| doi_str_mv | 10.1002/cncr.32332 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2289561709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2289561709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3932-30adfe91d39ba36e50dc7241d14c93549bfb48120c3d054e500dad5b7c28c0f63</originalsourceid><addsrcrecordid>eNp9kc9u1EAMxkeIim4LFx4AWeKGlHb-JJsMNxRBQaqKBK3ELXJmnJKSzJSZyVZ74xF65-14EmbZwpGLLcs_f7L9MfZc8BPBuTw1zoQTJZWSj9hKcF0XXJTyMVtxzpuiKtWXQ3YU400ua1mpJ-xQCVkJpZsV-9l6FylsMI0bghkdXtNMLoEfYPJ3v37chzF-g9vgY8JEYNAZCoCzd9ew9UuOGwpxieAnmxt5FkYH6SvBlRsTWfi8m4uv4TKQsxHQWfBLMn6mCEPwMyA4v6EJXN7BO5zAYsIeIz1lBwNOkZ495GN29e7tZfu-OP949qF9c14YpZUsFEc7kBZW6R7VmipuTS1LYUVptKpK3Q992QjJjbK8KnOfW7RVXxvZGD6s1TF7udfNV35fKKbuxi8hbxI7KRtdrUXNdaZe7SmTfxEDDd1tGGcM207wbudDt_Oh--NDhl88SC79TPYf-vfxGRB74G6caPsfqa69aD_tRX8DZFyWgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289561709</pqid></control><display><type>article</type><title>Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Mahal, Amandeep R. ; Butler, Santino ; Franco, Idalid ; Muralidhar, Vinayak ; Larios, Dalia ; Pike, Luke R. G. ; Zhao, Shuang G. ; Sanford, Nina N. ; Dess, Robert T. ; Feng, Felix Y. ; D’Amico, Anthony V. ; Spratt, Daniel E. ; Yu, James B. ; Nguyen, Paul L. ; Rebbeck, Timothy R. ; Mahal, Brandon A.</creator><creatorcontrib>Mahal, Amandeep R. ; Butler, Santino ; Franco, Idalid ; Muralidhar, Vinayak ; Larios, Dalia ; Pike, Luke R. G. ; Zhao, Shuang G. ; Sanford, Nina N. ; Dess, Robert T. ; Feng, Felix Y. ; D’Amico, Anthony V. ; Spratt, Daniel E. ; Yu, James B. ; Nguyen, Paul L. ; Rebbeck, Timothy R. ; Mahal, Brandon A.</creatorcontrib><description>Background
Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative management for LRPC and associated short‐term outcomes in young versus older men in the United States.
Methods
The nonpublic Surveillance, Epidemiology, and End Results Prostate with Active Surveillance/Watchful Waiting (AS/WW) Database identified 50,302 men who were diagnosed with LRPC from 2010 through 2015. AS/WW rates in the United States were stratified by age (≤55 vs ≥56 years). Prostate cancer‐specific mortality and overall mortality were defined by initial management type (AS/WW vs definitive treatment [referent]) and age.
Results
AS/WW utilization increased from 8.61% (2010) to 34.56% (2015) among men aged ≤55 years (P for trend <0.001) and from 15.99% to 43.81% among men aged ≥56 years (P for trend <.001). Among patients who had ≤2 positive biopsy cores, AS/WW rates increased from 12.90% to 48.78% for men aged ≤55 years and from 21.85% to 58.01% for men aged ≥56 years. Among patients who had ≥3 positive biopsy cores, AS/WW rates increased from 3.89% to 22.45% for men aged ≤55 years and from 10.05% to 28.49% for men aged ≥56 years (all P for trend <.001). Five‐year prostate cancer‐specific mortality rates were <0.30% across age and initial management type subgroups.
Conclusions
AS/WW rates quadrupled for patients aged ≤55 years from 2010 to 2015, with favorable short‐term outcomes. These findings demonstrate the short‐term safety and increasing acceptance of AS/WW for both younger and older patients. However, there are still higher absolute rates of AS/WW in older patients (P < .001), suggesting some national ambivalence toward AS/WW in younger patients.
Debate exists regarding active surveillance/watchful waiting for patients who have low‐risk prostate cancer, particularly in younger men. The authors demonstrate that there is increasing acceptance of conservative management with active surveillance/watchful waiting for both younger and older patients in the United States with favorable short‐term outcomes.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.32332</identifier><identifier>PMID: 31251398</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>active surveillance ; Age ; Age Factors ; Aged ; Biopsy ; Biopsy, Large-Core Needle ; conservative treatment ; Conservative Treatment - methods ; Cores ; Databases, Factual - statistics & numerical data ; Epidemiology ; Follow-Up Studies ; Health risks ; Humans ; low‐risk prostate cancer ; Male ; Management ; Middle Aged ; Mortality ; Oncology ; Prostate - pathology ; Prostate cancer ; Prostate-Specific Antigen - blood ; prostatic neoplasms ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - therapy ; Quality of Life ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Risk management ; Subgroups ; Surveillance ; Survival Analysis ; Trends ; United States - epidemiology ; watchful waiting ; Watchful Waiting - methods</subject><ispartof>Cancer, 2019-10, Vol.125 (19), p.3338-3346</ispartof><rights>2019 American Cancer Society</rights><rights>2019 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3932-30adfe91d39ba36e50dc7241d14c93549bfb48120c3d054e500dad5b7c28c0f63</citedby><cites>FETCH-LOGICAL-c3932-30adfe91d39ba36e50dc7241d14c93549bfb48120c3d054e500dad5b7c28c0f63</cites><orcidid>0000-0002-2631-1902 ; 0000-0002-5973-4741 ; 0000-0003-3036-334X ; 0000-0002-3119-3226 ; 0000-0003-4157-9437 ; 0000-0003-2331-3758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.32332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.32332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31251398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahal, Amandeep R.</creatorcontrib><creatorcontrib>Butler, Santino</creatorcontrib><creatorcontrib>Franco, Idalid</creatorcontrib><creatorcontrib>Muralidhar, Vinayak</creatorcontrib><creatorcontrib>Larios, Dalia</creatorcontrib><creatorcontrib>Pike, Luke R. G.</creatorcontrib><creatorcontrib>Zhao, Shuang G.</creatorcontrib><creatorcontrib>Sanford, Nina N.</creatorcontrib><creatorcontrib>Dess, Robert T.</creatorcontrib><creatorcontrib>Feng, Felix Y.</creatorcontrib><creatorcontrib>D’Amico, Anthony V.</creatorcontrib><creatorcontrib>Spratt, Daniel E.</creatorcontrib><creatorcontrib>Yu, James B.</creatorcontrib><creatorcontrib>Nguyen, Paul L.</creatorcontrib><creatorcontrib>Rebbeck, Timothy R.</creatorcontrib><creatorcontrib>Mahal, Brandon A.</creatorcontrib><title>Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative management for LRPC and associated short‐term outcomes in young versus older men in the United States.
Methods
The nonpublic Surveillance, Epidemiology, and End Results Prostate with Active Surveillance/Watchful Waiting (AS/WW) Database identified 50,302 men who were diagnosed with LRPC from 2010 through 2015. AS/WW rates in the United States were stratified by age (≤55 vs ≥56 years). Prostate cancer‐specific mortality and overall mortality were defined by initial management type (AS/WW vs definitive treatment [referent]) and age.
Results
AS/WW utilization increased from 8.61% (2010) to 34.56% (2015) among men aged ≤55 years (P for trend <0.001) and from 15.99% to 43.81% among men aged ≥56 years (P for trend <.001). Among patients who had ≤2 positive biopsy cores, AS/WW rates increased from 12.90% to 48.78% for men aged ≤55 years and from 21.85% to 58.01% for men aged ≥56 years. Among patients who had ≥3 positive biopsy cores, AS/WW rates increased from 3.89% to 22.45% for men aged ≤55 years and from 10.05% to 28.49% for men aged ≥56 years (all P for trend <.001). Five‐year prostate cancer‐specific mortality rates were <0.30% across age and initial management type subgroups.
Conclusions
AS/WW rates quadrupled for patients aged ≤55 years from 2010 to 2015, with favorable short‐term outcomes. These findings demonstrate the short‐term safety and increasing acceptance of AS/WW for both younger and older patients. However, there are still higher absolute rates of AS/WW in older patients (P < .001), suggesting some national ambivalence toward AS/WW in younger patients.
Debate exists regarding active surveillance/watchful waiting for patients who have low‐risk prostate cancer, particularly in younger men. The authors demonstrate that there is increasing acceptance of conservative management with active surveillance/watchful waiting for both younger and older patients in the United States with favorable short‐term outcomes.</description><subject>active surveillance</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Biopsy, Large-Core Needle</subject><subject>conservative treatment</subject><subject>Conservative Treatment - methods</subject><subject>Cores</subject><subject>Databases, Factual - statistics & numerical data</subject><subject>Epidemiology</subject><subject>Follow-Up Studies</subject><subject>Health risks</subject><subject>Humans</subject><subject>low‐risk prostate cancer</subject><subject>Male</subject><subject>Management</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Prostate - pathology</subject><subject>Prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>prostatic neoplasms</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Risk management</subject><subject>Subgroups</subject><subject>Surveillance</subject><subject>Survival Analysis</subject><subject>Trends</subject><subject>United States - epidemiology</subject><subject>watchful waiting</subject><subject>Watchful Waiting - methods</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1EAMxkeIim4LFx4AWeKGlHb-JJsMNxRBQaqKBK3ELXJmnJKSzJSZyVZ74xF65-14EmbZwpGLLcs_f7L9MfZc8BPBuTw1zoQTJZWSj9hKcF0XXJTyMVtxzpuiKtWXQ3YU400ua1mpJ-xQCVkJpZsV-9l6FylsMI0bghkdXtNMLoEfYPJ3v37chzF-g9vgY8JEYNAZCoCzd9ew9UuOGwpxieAnmxt5FkYH6SvBlRsTWfi8m4uv4TKQsxHQWfBLMn6mCEPwMyA4v6EJXN7BO5zAYsIeIz1lBwNOkZ495GN29e7tZfu-OP949qF9c14YpZUsFEc7kBZW6R7VmipuTS1LYUVptKpK3Q992QjJjbK8KnOfW7RVXxvZGD6s1TF7udfNV35fKKbuxi8hbxI7KRtdrUXNdaZe7SmTfxEDDd1tGGcM207wbudDt_Oh--NDhl88SC79TPYf-vfxGRB74G6caPsfqa69aD_tRX8DZFyWgw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Mahal, Amandeep R.</creator><creator>Butler, Santino</creator><creator>Franco, Idalid</creator><creator>Muralidhar, Vinayak</creator><creator>Larios, Dalia</creator><creator>Pike, Luke R. G.</creator><creator>Zhao, Shuang G.</creator><creator>Sanford, Nina N.</creator><creator>Dess, Robert T.</creator><creator>Feng, Felix Y.</creator><creator>D’Amico, Anthony V.</creator><creator>Spratt, Daniel E.</creator><creator>Yu, James B.</creator><creator>Nguyen, Paul L.</creator><creator>Rebbeck, Timothy R.</creator><creator>Mahal, Brandon A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-2631-1902</orcidid><orcidid>https://orcid.org/0000-0002-5973-4741</orcidid><orcidid>https://orcid.org/0000-0003-3036-334X</orcidid><orcidid>https://orcid.org/0000-0002-3119-3226</orcidid><orcidid>https://orcid.org/0000-0003-4157-9437</orcidid><orcidid>https://orcid.org/0000-0003-2331-3758</orcidid></search><sort><creationdate>20191001</creationdate><title>Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database</title><author>Mahal, Amandeep R. ; Butler, Santino ; Franco, Idalid ; Muralidhar, Vinayak ; Larios, Dalia ; Pike, Luke R. G. ; Zhao, Shuang G. ; Sanford, Nina N. ; Dess, Robert T. ; Feng, Felix Y. ; D’Amico, Anthony V. ; Spratt, Daniel E. ; Yu, James B. ; Nguyen, Paul L. ; Rebbeck, Timothy R. ; Mahal, Brandon A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3932-30adfe91d39ba36e50dc7241d14c93549bfb48120c3d054e500dad5b7c28c0f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>active surveillance</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Biopsy, Large-Core Needle</topic><topic>conservative treatment</topic><topic>Conservative Treatment - methods</topic><topic>Cores</topic><topic>Databases, Factual - statistics & numerical data</topic><topic>Epidemiology</topic><topic>Follow-Up Studies</topic><topic>Health risks</topic><topic>Humans</topic><topic>low‐risk prostate cancer</topic><topic>Male</topic><topic>Management</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Prostate - pathology</topic><topic>Prostate cancer</topic><topic>Prostate-Specific Antigen - blood</topic><topic>prostatic neoplasms</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Risk management</topic><topic>Subgroups</topic><topic>Surveillance</topic><topic>Survival Analysis</topic><topic>Trends</topic><topic>United States - epidemiology</topic><topic>watchful waiting</topic><topic>Watchful Waiting - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahal, Amandeep R.</creatorcontrib><creatorcontrib>Butler, Santino</creatorcontrib><creatorcontrib>Franco, Idalid</creatorcontrib><creatorcontrib>Muralidhar, Vinayak</creatorcontrib><creatorcontrib>Larios, Dalia</creatorcontrib><creatorcontrib>Pike, Luke R. G.</creatorcontrib><creatorcontrib>Zhao, Shuang G.</creatorcontrib><creatorcontrib>Sanford, Nina N.</creatorcontrib><creatorcontrib>Dess, Robert T.</creatorcontrib><creatorcontrib>Feng, Felix Y.</creatorcontrib><creatorcontrib>D’Amico, Anthony V.</creatorcontrib><creatorcontrib>Spratt, Daniel E.</creatorcontrib><creatorcontrib>Yu, James B.</creatorcontrib><creatorcontrib>Nguyen, Paul L.</creatorcontrib><creatorcontrib>Rebbeck, Timothy R.</creatorcontrib><creatorcontrib>Mahal, Brandon A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahal, Amandeep R.</au><au>Butler, Santino</au><au>Franco, Idalid</au><au>Muralidhar, Vinayak</au><au>Larios, Dalia</au><au>Pike, Luke R. G.</au><au>Zhao, Shuang G.</au><au>Sanford, Nina N.</au><au>Dess, Robert T.</au><au>Feng, Felix Y.</au><au>D’Amico, Anthony V.</au><au>Spratt, Daniel E.</au><au>Yu, James B.</au><au>Nguyen, Paul L.</au><au>Rebbeck, Timothy R.</au><au>Mahal, Brandon A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>125</volume><issue>19</issue><spage>3338</spage><epage>3346</epage><pages>3338-3346</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
Management for men aged ≤55 years with low‐risk prostate cancer (LRPC) is debated given quality‐of‐life implications with definitive treatment versus the potential missed opportunity for cure with conservative management. The objective of this study was to define rates of conservative management for LRPC and associated short‐term outcomes in young versus older men in the United States.
Methods
The nonpublic Surveillance, Epidemiology, and End Results Prostate with Active Surveillance/Watchful Waiting (AS/WW) Database identified 50,302 men who were diagnosed with LRPC from 2010 through 2015. AS/WW rates in the United States were stratified by age (≤55 vs ≥56 years). Prostate cancer‐specific mortality and overall mortality were defined by initial management type (AS/WW vs definitive treatment [referent]) and age.
Results
AS/WW utilization increased from 8.61% (2010) to 34.56% (2015) among men aged ≤55 years (P for trend <0.001) and from 15.99% to 43.81% among men aged ≥56 years (P for trend <.001). Among patients who had ≤2 positive biopsy cores, AS/WW rates increased from 12.90% to 48.78% for men aged ≤55 years and from 21.85% to 58.01% for men aged ≥56 years. Among patients who had ≥3 positive biopsy cores, AS/WW rates increased from 3.89% to 22.45% for men aged ≤55 years and from 10.05% to 28.49% for men aged ≥56 years (all P for trend <.001). Five‐year prostate cancer‐specific mortality rates were <0.30% across age and initial management type subgroups.
Conclusions
AS/WW rates quadrupled for patients aged ≤55 years from 2010 to 2015, with favorable short‐term outcomes. These findings demonstrate the short‐term safety and increasing acceptance of AS/WW for both younger and older patients. However, there are still higher absolute rates of AS/WW in older patients (P < .001), suggesting some national ambivalence toward AS/WW in younger patients.
Debate exists regarding active surveillance/watchful waiting for patients who have low‐risk prostate cancer, particularly in younger men. The authors demonstrate that there is increasing acceptance of conservative management with active surveillance/watchful waiting for both younger and older patients in the United States with favorable short‐term outcomes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31251398</pmid><doi>10.1002/cncr.32332</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2631-1902</orcidid><orcidid>https://orcid.org/0000-0002-5973-4741</orcidid><orcidid>https://orcid.org/0000-0003-3036-334X</orcidid><orcidid>https://orcid.org/0000-0002-3119-3226</orcidid><orcidid>https://orcid.org/0000-0003-4157-9437</orcidid><orcidid>https://orcid.org/0000-0003-2331-3758</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 2019-10, Vol.125 (19), p.3338-3346 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | active surveillance Age Age Factors Aged Biopsy Biopsy, Large-Core Needle conservative treatment Conservative Treatment - methods Cores Databases, Factual - statistics & numerical data Epidemiology Follow-Up Studies Health risks Humans low‐risk prostate cancer Male Management Middle Aged Mortality Oncology Prostate - pathology Prostate cancer Prostate-Specific Antigen - blood prostatic neoplasms Prostatic Neoplasms - blood Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Quality of Life Retrospective Studies Risk Assessment Risk Factors Risk management Subgroups Surveillance Survival Analysis Trends United States - epidemiology watchful waiting Watchful Waiting - methods |
| title | Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database |
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