An Unprecedented Synthesis of 3,3‐Disubstituted Isochroman‐1,4‐diones Using Nitrones as Oxygen Atom Donors

An Unprecedented Synthesis of 3,3‐Disubstituted Isochroman‐1,4‐diones Using Nitrones as Oxygen Atom Donors

A one‐pot reaction of ninhydrin, N‐methyl‐C‐phenyl nitrone, and secondary amine leading to the unprecedented synthesis of 3,3‐disubstituted isochroman‐1,4‐diones is described here. In this reaction, nitrone acts as an oxygen atom donor producing an imine as a side product. The mild reaction conditio...

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Veröffentlicht in:Journal of heterocyclic chemistry 2019-09, Vol.56 (9), p.2333-2340
Hauptverfasser: Sathi, Vidya, Deepthi, Ani, Thomas, Noble V.
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Amines
Ninhydrin
Synthesis
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container_title Journal of heterocyclic chemistry
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creator Sathi, Vidya
Deepthi, Ani
Thomas, Noble V.
description A one‐pot reaction of ninhydrin, N‐methyl‐C‐phenyl nitrone, and secondary amine leading to the unprecedented synthesis of 3,3‐disubstituted isochroman‐1,4‐diones is described here. In this reaction, nitrone acts as an oxygen atom donor producing an imine as a side product. The mild reaction conditions, the flexibility of the secondary amines that can be used, the novelty of the product, and the good yields are the highlights of this reaction.
doi_str_mv 10.1002/jhet.3619
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subjects Amines
Ninhydrin
Synthesis
title An Unprecedented Synthesis of 3,3‐Disubstituted Isochroman‐1,4‐diones Using Nitrones as Oxygen Atom Donors
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