Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients
Background: Bone fractures strongly influence morbidity and mortality in elderly patients with dementia. The goal of this study was to examine whether difference in the type of dementia affects changes of bone mineral density (BMD) during hospitalization with rehabilitation programs. Methods: Nine...
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| Veröffentlicht in: | Geriatrics & gerontology international 2007-12, Vol.7 (4), p.363-370 |
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| creator | Suzuki, Atsuko Fukuo, Keisuke Yasuda, Osamu Taniguchi, Kazuhisa Kitano, Shoichi Ogihara, Toshio |
| description | Background: Bone fractures strongly influence morbidity and mortality in elderly patients with dementia. The goal of this study was to examine whether difference in the type of dementia affects changes of bone mineral density (BMD) during hospitalization with rehabilitation programs.
Methods: Ninety‐four Japanese elderly female patients were enrolled. BMD, Mini‐Mental State Examination (MMSE) scores, and levels of serum albumin, calcium‐related factors and urinary calcium excretion were measured.
Results: Multivariable analyses indicated that serum albumin levels and MMSE scores were positively correlated with changes in BMD after 2 years hospitalization. Significant reduction of BMD levels after hospitalization were observed in patients with severe dementia (MMSE scores, |
| doi_str_mv | 10.1111/j.1447-0594.2007.00426.x |
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Methods: Ninety‐four Japanese elderly female patients were enrolled. BMD, Mini‐Mental State Examination (MMSE) scores, and levels of serum albumin, calcium‐related factors and urinary calcium excretion were measured.
Results: Multivariable analyses indicated that serum albumin levels and MMSE scores were positively correlated with changes in BMD after 2 years hospitalization. Significant reduction of BMD levels after hospitalization were observed in patients with severe dementia (MMSE scores, <10) or with severe malnutrition (serum albumin, <2.0). We next classified our subjects into three groups according to the 4th edn of the Diagnostic and Statistical Manual criteria: non‐dementia (ND), Alzheimer's disease (AD) and vascular dementia (VaD). Although there were no significant differences in age and physical activities among the groups; the levels of BMD were maintained in AD as well as ND but not in VaD. Notably, calcium excretion levels were significantly decreased after hospitalization in AD as well as ND but not in VaD. Serum 25(OH)D levels were also restored in AD but not in VaD. In addition, the nutritional status significantly improved in AD but not in VaD.
Conclusion: The levels of BMD were maintained and the nutritional status was improved in AD but not in VaD for 2 years hospitalization with rehabilitation programs. These results suggest that different programs including nutritional support may be necessary for maintaining BMD levels in VaD as compared with AD during hospitalization.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/j.1447-0594.2007.00426.x</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Bone density ; bone mineral density ; Dementia ; Mini-Mental State Examination ; Nutrition ; Older people ; senile dementia ; Women</subject><ispartof>Geriatrics & gerontology international, 2007-12, Vol.7 (4), p.363-370</ispartof><rights>2007 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3606-dbbf142360d8c0a2cfbaf43e3dc586ddb2239dd6bccf64faa258f8ad6dfc25253</citedby><cites>FETCH-LOGICAL-c3606-dbbf142360d8c0a2cfbaf43e3dc586ddb2239dd6bccf64faa258f8ad6dfc25253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0594.2007.00426.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0594.2007.00426.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Suzuki, Atsuko</creatorcontrib><creatorcontrib>Fukuo, Keisuke</creatorcontrib><creatorcontrib>Yasuda, Osamu</creatorcontrib><creatorcontrib>Taniguchi, Kazuhisa</creatorcontrib><creatorcontrib>Kitano, Shoichi</creatorcontrib><creatorcontrib>Ogihara, Toshio</creatorcontrib><title>Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients</title><title>Geriatrics & gerontology international</title><description>Background: Bone fractures strongly influence morbidity and mortality in elderly patients with dementia. The goal of this study was to examine whether difference in the type of dementia affects changes of bone mineral density (BMD) during hospitalization with rehabilitation programs.
Methods: Ninety‐four Japanese elderly female patients were enrolled. BMD, Mini‐Mental State Examination (MMSE) scores, and levels of serum albumin, calcium‐related factors and urinary calcium excretion were measured.
Results: Multivariable analyses indicated that serum albumin levels and MMSE scores were positively correlated with changes in BMD after 2 years hospitalization. Significant reduction of BMD levels after hospitalization were observed in patients with severe dementia (MMSE scores, <10) or with severe malnutrition (serum albumin, <2.0). We next classified our subjects into three groups according to the 4th edn of the Diagnostic and Statistical Manual criteria: non‐dementia (ND), Alzheimer's disease (AD) and vascular dementia (VaD). Although there were no significant differences in age and physical activities among the groups; the levels of BMD were maintained in AD as well as ND but not in VaD. Notably, calcium excretion levels were significantly decreased after hospitalization in AD as well as ND but not in VaD. Serum 25(OH)D levels were also restored in AD but not in VaD. In addition, the nutritional status significantly improved in AD but not in VaD.
Conclusion: The levels of BMD were maintained and the nutritional status was improved in AD but not in VaD for 2 years hospitalization with rehabilitation programs. These results suggest that different programs including nutritional support may be necessary for maintaining BMD levels in VaD as compared with AD during hospitalization.</description><subject>Bone density</subject><subject>bone mineral density</subject><subject>Dementia</subject><subject>Mini-Mental State Examination</subject><subject>Nutrition</subject><subject>Older people</subject><subject>senile dementia</subject><subject>Women</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhiMEEqX0HSwunBJsJ3GyEpeqhVC1Kq0E6tGa2GPWS-IstkN3-zq8KM4u6hlf_Msz32_N_FlGGC1YOh82BauqJqf1qio4pU1BacVFsXuRnTwXXh50lbO6Fa-zNyFsKGXNirGT7M-lNQY9ukjUGtwPDGQypJ8cktE69DAQjS7YuCfgNHFz9DbayaX3ECHOgYCJ6Ml6ClsbYbBPsJRJj_ER0ZHfENQ8gE8uY_rEwsHmfHhaox3Rvw9E24AQkFhHcNDohz0xOMKAZJusEhPeZq8MDAHP_t2n2ffPn75dfMlvvnZXF-c3uSoFFbnue8MqnrRuFQWuTA-mKrHUKs2tdc95udJa9EoZURkAXremBS20UbzmdXmavTv6bv30a8YQ5WaafRo1SM7bVoiKr1JTe2xSfgrBo5Fbb0fwe8moXBKRG7ksXi6Ll0si8pCI3CX04xF9tAPu_5uTXXeVRMLzI25DxN0zDv6nFE3Z1PLhtpO396K7vL5r5XX5FzLWpo0</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Suzuki, Atsuko</creator><creator>Fukuo, Keisuke</creator><creator>Yasuda, Osamu</creator><creator>Taniguchi, Kazuhisa</creator><creator>Kitano, Shoichi</creator><creator>Ogihara, Toshio</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>200712</creationdate><title>Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients</title><author>Suzuki, Atsuko ; Fukuo, Keisuke ; Yasuda, Osamu ; Taniguchi, Kazuhisa ; Kitano, Shoichi ; Ogihara, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3606-dbbf142360d8c0a2cfbaf43e3dc586ddb2239dd6bccf64faa258f8ad6dfc25253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Bone density</topic><topic>bone mineral density</topic><topic>Dementia</topic><topic>Mini-Mental State Examination</topic><topic>Nutrition</topic><topic>Older people</topic><topic>senile dementia</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Atsuko</creatorcontrib><creatorcontrib>Fukuo, Keisuke</creatorcontrib><creatorcontrib>Yasuda, Osamu</creatorcontrib><creatorcontrib>Taniguchi, Kazuhisa</creatorcontrib><creatorcontrib>Kitano, Shoichi</creatorcontrib><creatorcontrib>Ogihara, Toshio</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Atsuko</au><au>Fukuo, Keisuke</au><au>Yasuda, Osamu</au><au>Taniguchi, Kazuhisa</au><au>Kitano, Shoichi</au><au>Ogihara, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients</atitle><jtitle>Geriatrics & gerontology international</jtitle><date>2007-12</date><risdate>2007</risdate><volume>7</volume><issue>4</issue><spage>363</spage><epage>370</epage><pages>363-370</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Background: Bone fractures strongly influence morbidity and mortality in elderly patients with dementia. The goal of this study was to examine whether difference in the type of dementia affects changes of bone mineral density (BMD) during hospitalization with rehabilitation programs.
Methods: Ninety‐four Japanese elderly female patients were enrolled. BMD, Mini‐Mental State Examination (MMSE) scores, and levels of serum albumin, calcium‐related factors and urinary calcium excretion were measured.
Results: Multivariable analyses indicated that serum albumin levels and MMSE scores were positively correlated with changes in BMD after 2 years hospitalization. Significant reduction of BMD levels after hospitalization were observed in patients with severe dementia (MMSE scores, <10) or with severe malnutrition (serum albumin, <2.0). We next classified our subjects into three groups according to the 4th edn of the Diagnostic and Statistical Manual criteria: non‐dementia (ND), Alzheimer's disease (AD) and vascular dementia (VaD). Although there were no significant differences in age and physical activities among the groups; the levels of BMD were maintained in AD as well as ND but not in VaD. Notably, calcium excretion levels were significantly decreased after hospitalization in AD as well as ND but not in VaD. Serum 25(OH)D levels were also restored in AD but not in VaD. In addition, the nutritional status significantly improved in AD but not in VaD.
Conclusion: The levels of BMD were maintained and the nutritional status was improved in AD but not in VaD for 2 years hospitalization with rehabilitation programs. These results suggest that different programs including nutritional support may be necessary for maintaining BMD levels in VaD as compared with AD during hospitalization.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><doi>10.1111/j.1447-0594.2007.00426.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Bone density bone mineral density Dementia Mini-Mental State Examination Nutrition Older people senile dementia Women |
| title | Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients |
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