Estrogen-functionalized liposomes grafted with glutathione-responsive sheddable chotooligosaccharides for the therapy of osteosarcoma

An estrogen (ES)-functionalized cationic liposomal system was developed and exploited for targeted delivery to osteosarcoma. Natural biocompatible chotooligosaccharides (COS, MW2-5 KDa) were covalently tethered to the liposomal surface through a disulfate bond (-SS-) to confer reduction-responsive C...

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Veröffentlicht in:	Drug delivery 2018-11, Vol.25 (1), p.900-908
Hauptverfasser:	Yin, Xuelei, Feng, Shuaishuai, Chi, Yingying, Liu, Jinhu, Sun, Kaoxiang, Guo, Chuanyou, Wu, Zimei
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone cancer cationic liposomes chotooligosaccharides Cytotoxicity Estrogen-functionalized osteosarcoma Polyethylene glycol reduction-sensitivity Sarcoma targeting
Online-Zugang:	Volltext
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