Novel retinoblastoma mutation abrogating the interaction to E 2 F 2/3, but not E 2 F 1, led to selective suppression of thyroid tumors

Mutant mouse models are indispensable tools for clarifying gene functions and elucidating the pathogenic mechanisms of human diseases. Here, we describe novel cancer models bearing point mutations in the retinoblastoma gene ( Rb1 ) generated by N ‐ethyl‐ N ‐nitrosourea mutagenesis. Two mutations in...

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