Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Different ketoreductases (KREDs) have been used to promote a highly selective reduction of several 1-aryl-2-(azaaryl)ethanones (azaaryl = pyridinyl, quinolin-2-yl), the corresponding secondary alcohols being obtained with very high yields and enantiomeric excesses (ee > 99%). The absolute configu...

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Veröffentlicht in:	Organic & biomolecular chemistry 2019-09, Vol.17 (35), p.8214-822
Hauptverfasser:	Liz, Ramón, Liardo, Elisa, Rebolledo, Francisca
Format:	Artikel
Sprache:	eng
Schlagworte:	Absolute configuration Alcohol Alcohols Aromatic compounds Biological activity Ethanol High-performance liquid chromatography Liquid chromatography NMR Nuclear magnetic resonance Optical activity Protons Shielding
Online-Zugang:	Volltext
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