Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity

Psychological distress has long been suspected to influence cancer incidence and mortality. It remains largely unknown whether and how stress affects the efficacy of anticancer therapies. We observed that social defeat caused anxiety-like behaviors in mice and dampened therapeutic responses against...

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Veröffentlicht in:	Nature medicine 2019-09, Vol.25 (9), p.1428-1441
Hauptverfasser:	Yang, Heng, Xia, Lin, Chen, Jian, Zhang, Shuqing, Martin, Vincent, Li, Qingqing, Lin, Shangqing, Chen, Jinfeng, Calmette, Joseph, Lu, Min, Fu, Lingyi, Yang, Jie, Pan, Zhizhong, Yu, Kuai, He, Jingjing, Morand, Eric, Schlecht-Louf, Géraldine, Krzysiek, Roman, Zitvogel, Laurence, Kang, Boxi, Zhang, Zeming, Leader, Andrew, Zhou, Penghui, Lanfumey, Laurence, Shi, Minxin, Kroemer, Guido, Ma, Yuting
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2502 631/250/251 631/250/580 631/67/1059 631/67/580 Animal models Animals Anticancer properties Anxiety Anxiety - blood Anxiety - chemically induced Anxiety - immunology Anxiety - psychology Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinogens Carcinogens - toxicity Cell activation Clonal deletion Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - psychology Corticosterone Corticosterone - blood Cortisol Dendritic cells Dendritic Cells - transplantation Gene Expression Regulation, Neoplastic Glucocorticoids Glucocorticoids - pharmacology Humans Hydrocortisone - blood Immunity Immunity, Cellular Immunosurveillance Infectious Diseases Interferon Leukocytes Lung Neoplasms - blood Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - psychology Lymphocyte Activation - genetics Lymphocytes Lymphocytes T Metabolic Diseases Mice Molecular Medicine Monitoring, Immunologic - methods Mood Neoplasms - chemically induced Neoplasms - genetics Neoplasms - immunology Neoplasms - psychology Neurosciences Receptors, Glucocorticoid - antagonists & inhibitors Signal Transduction - drug effects Social interactions Stomach Neoplasms - blood Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach Neoplasms - psychology Stress, Psychological - chemically induced Stress, Psychological - genetics Stress, Psychological - immunology Stress, Psychological - therapy Supplements Therapy Transcription Factors - genetics Transcription Factors - immunology Tumors γ-Interferon
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