X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery
The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2019-09, Vol.31 (37), p.e1903443-n/a |
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| creator | Deng, Hongzhang Lin, Lisen Wang, Sheng Yu, Guocan Zhou, Zijian Liu, Yijing Niu, Gang Song, Jibin Chen, Xiaoyuan |
| description | The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine‐modified ZnS (ZnS‐A) nanoparticles (NPs) via nucleobase pairing. The ZnS‐A NPs convert X‐rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS‐A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.
X‐ray‐responsive bionic nanocapsules with reversible and tunable permeability are prepared by cross‐linking the self‐assembled triblock polymer poly(ethylene glycol)‐b‐polythymine‐b‐polyazobenzene (PETAzo) with adenine‐modified zinc sulfide nanoparticles (ZnS‐A NPs) through nucleobase pairing. The ZnS‐A NPs cross‐link PETAzo and convert X‐rays to UV light to induce azobenzene isomerization, which allows controlled diffusion of the active payloads across the bilayer membrane. |
| doi_str_mv | 10.1002/adma.201903443 |
| format | Article |
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X‐ray‐responsive bionic nanocapsules with reversible and tunable permeability are prepared by cross‐linking the self‐assembled triblock polymer poly(ethylene glycol)‐b‐polythymine‐b‐polyazobenzene (PETAzo) with adenine‐modified zinc sulfide nanoparticles (ZnS‐A NPs) through nucleobase pairing. The ZnS‐A NPs cross‐link PETAzo and convert X‐rays to UV light to induce azobenzene isomerization, which allows controlled diffusion of the active payloads across the bilayer membrane.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201903443</identifier><identifier>PMID: 31379091</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Accumulation ; Active control ; Adenine - chemistry ; Adsorption ; Animals ; Anticancer properties ; Azo Compounds - chemistry ; azobenzene ; Base Pairing ; Bilayers ; Biomimetic Materials - chemistry ; Bionics ; Cell Line, Tumor ; Control stability ; controlled drug release ; Disruption ; Drug Carriers - chemistry ; Drug delivery systems ; Humans ; Isomerism ; Mice ; Nanocapsules - chemistry ; Nanoparticles ; nucleobase pairing ; Payloads ; Permeability ; Photochemical Processes ; Remote control ; Serum Albumin, Bovine - chemistry ; Sulfides - chemistry ; Thymine - chemistry ; Ultraviolet radiation ; X-Rays ; Zinc Compounds - chemistry ; Zinc sulfide</subject><ispartof>Advanced materials (Weinheim), 2019-09, Vol.31 (37), p.e1903443-n/a</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4503-81afb23f571aed029d25c435483f24a0eb0f0615863565a9c35bcfb2feb0f4ef3</citedby><cites>FETCH-LOGICAL-c4503-81afb23f571aed029d25c435483f24a0eb0f0615863565a9c35bcfb2feb0f4ef3</cites><orcidid>0000-0002-9622-0870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201903443$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201903443$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31379091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Hongzhang</creatorcontrib><creatorcontrib>Lin, Lisen</creatorcontrib><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Yu, Guocan</creatorcontrib><creatorcontrib>Zhou, Zijian</creatorcontrib><creatorcontrib>Liu, Yijing</creatorcontrib><creatorcontrib>Niu, Gang</creatorcontrib><creatorcontrib>Song, Jibin</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><title>X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine‐modified ZnS (ZnS‐A) nanoparticles (NPs) via nucleobase pairing. The ZnS‐A NPs convert X‐rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS‐A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.
X‐ray‐responsive bionic nanocapsules with reversible and tunable permeability are prepared by cross‐linking the self‐assembled triblock polymer poly(ethylene glycol)‐b‐polythymine‐b‐polyazobenzene (PETAzo) with adenine‐modified zinc sulfide nanoparticles (ZnS‐A NPs) through nucleobase pairing. The ZnS‐A NPs cross‐link PETAzo and convert X‐rays to UV light to induce azobenzene isomerization, which allows controlled diffusion of the active payloads across the bilayer membrane.</description><subject>Accumulation</subject><subject>Active control</subject><subject>Adenine - chemistry</subject><subject>Adsorption</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Azo Compounds - chemistry</subject><subject>azobenzene</subject><subject>Base Pairing</subject><subject>Bilayers</subject><subject>Biomimetic Materials - chemistry</subject><subject>Bionics</subject><subject>Cell Line, Tumor</subject><subject>Control stability</subject><subject>controlled drug release</subject><subject>Disruption</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery systems</subject><subject>Humans</subject><subject>Isomerism</subject><subject>Mice</subject><subject>Nanocapsules - chemistry</subject><subject>Nanoparticles</subject><subject>nucleobase pairing</subject><subject>Payloads</subject><subject>Permeability</subject><subject>Photochemical Processes</subject><subject>Remote control</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Sulfides - chemistry</subject><subject>Thymine - chemistry</subject><subject>Ultraviolet radiation</subject><subject>X-Rays</subject><subject>Zinc Compounds - chemistry</subject><subject>Zinc sulfide</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1uFDEUhS0EIkugpUSWqGe5_psdl8suP5FCiARIdCOP5zpy5B0v9kzQUFFT8Yw8CV42hJLGluzvfFf3EPKUwZIB8Bem35klB6ZBSCnukQVTnFUStLpPFqCFqnQtmxPyKOdrANA11A_JiWBipUGzBfnx-df3n8nM5dzEYUwxBOzpSx_MjIleYtqh6Xzw40yjK-9x8JZemCFas89TwEw_jH-AbyXWzfRisgFjZzLSS-OTH67o2TBiMnYs2UxdLNYpZDP6gHSbpiu6xeBvMM2PyQNnQsYnt_cp-fT61cfN2-r8_Zuzzfq8slKBqBpmXMeFUytmsAeue66sFEo2wnFpADtwUDPV1ELVymgrVGdLwh0-JDpxSp4fvfsUv0yYx_Y6TmkoI1vOm1UZwjgUanmkbIo5J3TtPvmdSXPLoD1U3x6qb--qL4Fnt9qp22F_h__tugD6CHwtq8__0bXr7bv1P_lvvyuUTw</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Deng, Hongzhang</creator><creator>Lin, Lisen</creator><creator>Wang, Sheng</creator><creator>Yu, Guocan</creator><creator>Zhou, Zijian</creator><creator>Liu, Yijing</creator><creator>Niu, Gang</creator><creator>Song, Jibin</creator><creator>Chen, Xiaoyuan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid></search><sort><creationdate>20190901</creationdate><title>X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery</title><author>Deng, Hongzhang ; Lin, Lisen ; Wang, Sheng ; Yu, Guocan ; Zhou, Zijian ; Liu, Yijing ; Niu, Gang ; Song, Jibin ; Chen, Xiaoyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4503-81afb23f571aed029d25c435483f24a0eb0f0615863565a9c35bcfb2feb0f4ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Accumulation</topic><topic>Active control</topic><topic>Adenine - chemistry</topic><topic>Adsorption</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>Azo Compounds - chemistry</topic><topic>azobenzene</topic><topic>Base Pairing</topic><topic>Bilayers</topic><topic>Biomimetic Materials - chemistry</topic><topic>Bionics</topic><topic>Cell Line, Tumor</topic><topic>Control stability</topic><topic>controlled drug release</topic><topic>Disruption</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery systems</topic><topic>Humans</topic><topic>Isomerism</topic><topic>Mice</topic><topic>Nanocapsules - chemistry</topic><topic>Nanoparticles</topic><topic>nucleobase pairing</topic><topic>Payloads</topic><topic>Permeability</topic><topic>Photochemical Processes</topic><topic>Remote control</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Sulfides - chemistry</topic><topic>Thymine - chemistry</topic><topic>Ultraviolet radiation</topic><topic>X-Rays</topic><topic>Zinc Compounds - chemistry</topic><topic>Zinc sulfide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Hongzhang</creatorcontrib><creatorcontrib>Lin, Lisen</creatorcontrib><creatorcontrib>Wang, Sheng</creatorcontrib><creatorcontrib>Yu, Guocan</creatorcontrib><creatorcontrib>Zhou, Zijian</creatorcontrib><creatorcontrib>Liu, Yijing</creatorcontrib><creatorcontrib>Niu, Gang</creatorcontrib><creatorcontrib>Song, Jibin</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Hongzhang</au><au>Lin, Lisen</au><au>Wang, Sheng</au><au>Yu, Guocan</au><au>Zhou, Zijian</au><au>Liu, Yijing</au><au>Niu, Gang</au><au>Song, Jibin</au><au>Chen, Xiaoyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>31</volume><issue>37</issue><spage>e1903443</spage><epage>n/a</epage><pages>e1903443-n/a</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine‐modified ZnS (ZnS‐A) nanoparticles (NPs) via nucleobase pairing. The ZnS‐A NPs convert X‐rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS‐A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.
X‐ray‐responsive bionic nanocapsules with reversible and tunable permeability are prepared by cross‐linking the self‐assembled triblock polymer poly(ethylene glycol)‐b‐polythymine‐b‐polyazobenzene (PETAzo) with adenine‐modified zinc sulfide nanoparticles (ZnS‐A NPs) through nucleobase pairing. The ZnS‐A NPs cross‐link PETAzo and convert X‐rays to UV light to induce azobenzene isomerization, which allows controlled diffusion of the active payloads across the bilayer membrane.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31379091</pmid><doi>10.1002/adma.201903443</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Accumulation Active control Adenine - chemistry Adsorption Animals Anticancer properties Azo Compounds - chemistry azobenzene Base Pairing Bilayers Biomimetic Materials - chemistry Bionics Cell Line, Tumor Control stability controlled drug release Disruption Drug Carriers - chemistry Drug delivery systems Humans Isomerism Mice Nanocapsules - chemistry Nanoparticles nucleobase pairing Payloads Permeability Photochemical Processes Remote control Serum Albumin, Bovine - chemistry Sulfides - chemistry Thymine - chemistry Ultraviolet radiation X-Rays Zinc Compounds - chemistry Zinc sulfide |
| title | X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery |
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