Modeling the Effect of Mucin Binding in the Gut on Drug Delivery

An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of mathematical biology 2019-09, Vol.81 (9), p.3460-3476
Hauptverfasser:	Saltzman, Jeffrey, Bendtsen, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Applied mathematics Binding Cell Biology Computer Simulation Diffusion layers Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug Delivery Systems - statistics & numerical data Drug Development - methods Drug Development - statistics & numerical data Excretion Humans Intestinal Absorption Intestinal Mucosa - metabolism Intestine Life Sciences Mathematical and Computational Biology Mathematical Concepts Mathematical models Mathematics Mathematics and Statistics Metabolism Models, Biological Mucin Mucins - metabolism Mucus Nonlinear Dynamics Pharmaceutical Preparations - administration & dosage Pharmacokinetics Protein Binding Proteins Special Issue: Mathematics to Support Drug Discovery and Development
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!