Modeling the Effect of Mucin Binding in the Gut on Drug Delivery
An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compo...
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| Veröffentlicht in: | Bulletin of mathematical biology 2019-09, Vol.81 (9), p.3460-3476 |
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| container_title | Bulletin of mathematical biology |
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| creator | Saltzman, Jeffrey Bendtsen, Claus |
| description | An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compounds within the mucus layer of the intestines. Analysis of this model yields simple, measurable criteria for the successful mucin layer traversal of drug compound. |
| doi_str_mv | 10.1007/s11538-018-0417-3 |
| format | Article |
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| ispartof | Bulletin of mathematical biology, 2019-09, Vol.81 (9), p.3460-3476 |
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| subjects | Absorption Animals Applied mathematics Binding Cell Biology Computer Simulation Diffusion layers Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug Delivery Systems - statistics & numerical data Drug Development - methods Drug Development - statistics & numerical data Excretion Humans Intestinal Absorption Intestinal Mucosa - metabolism Intestine Life Sciences Mathematical and Computational Biology Mathematical Concepts Mathematical models Mathematics Mathematics and Statistics Metabolism Models, Biological Mucin Mucins - metabolism Mucus Nonlinear Dynamics Pharmaceutical Preparations - administration & dosage Pharmacokinetics Protein Binding Proteins Special Issue: Mathematics to Support Drug Discovery and Development |
| title | Modeling the Effect of Mucin Binding in the Gut on Drug Delivery |
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