Stereospecific interactions between histidine and monoclonal antibodies

Histidine is a frequently used buffer in the final formulation of many commercialized monoclonal antibodies (mAbs), with histidine helping to stabilize the antibody during storage in addition to its buffering function. The objective of this study was to examine the stereospecificity of any histidine...

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Veröffentlicht in:	Biotechnology and bioengineering 2019-10, Vol.116 (10), p.2632-2639
Hauptverfasser:	Baek, Youngbin, Emami, Parinaz, Singh, Nripen, Ilott, Andrew, Sahin, Erinc, Zydney, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	buffer interactions Buffers Calorimetry Commercialization formulation Histidine Light scattering Molecular dynamics Monoclonal antibodies monoclonal antibody Stereospecificity Titration Titration calorimetry
Online-Zugang:	Volltext
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