Methadone Maintenance and Breastfeeding in the Neonatal Period
In a sample of methadone-maintained breastfeeding women and a matched group of formula-feeding women, this study evaluated concentrations of methadone in breast milk among breastfeeding women and concentrations of methadone in maternal and infant plasma in both groups. Eight methadone-maintained (do...
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| Veröffentlicht in: | Pediatrics (Evanston) 2008-01, Vol.121 (1), p.106-114 |
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| creator | Jansson, Lauren M Choo, Robin Velez, Martha L Harrow, Cheryl Schroeder, Jennifer R Shakleya, Diaa M Huestis, Marilyn A |
| description | In a sample of methadone-maintained breastfeeding women and a matched group of formula-feeding women, this study evaluated concentrations of methadone in breast milk among breastfeeding women and concentrations of methadone in maternal and infant plasma in both groups.
Eight methadone-maintained (dose: 50-105 mg/day), lactating women provided blood and breast milk specimens on days 1, 2, 3, 4, 14, and 30 after delivery, at the times of trough and peak maternal methadone levels. Paired specimens of foremilk and hindmilk were obtained at each sampling time. Eight matched formula-feeding subjects provided blood samples on the same days. Infant blood samples for both groups were obtained on day 14. Urine toxicological screening between 36 weeks of gestation and 30 days after the birth confirmed that subjects were not using illicit substances in the perinatal period.
Concentrations of methadone in breast milk were low (range: 21.0-462.0 ng/mL) and not related to maternal dose. There was a significant increase in methadone concentrations in breast milk over time for all 4 sampling times. Concentrations of methadone in maternal plasma were not different between groups and were unrelated to maternal dose. Concentrations of methadone in infant plasma were low (range: 2.2-8.1 ng/mL) in all samples. Infants in both groups underwent neurobehavioral assessments on days 3, 14, and 30; there were no significant effects of breastfeeding on neurobehavioral outcomes. Fewer infants in the breastfed group required pharmacotherapy for neonatal abstinence syndrome, but this was not a statistically significant finding.
Results contribute to the recommendation of breastfeeding for methadone-maintained women. |
| doi_str_mv | 10.1542/peds.2007-1182 |
| format | Article |
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Eight methadone-maintained (dose: 50-105 mg/day), lactating women provided blood and breast milk specimens on days 1, 2, 3, 4, 14, and 30 after delivery, at the times of trough and peak maternal methadone levels. Paired specimens of foremilk and hindmilk were obtained at each sampling time. Eight matched formula-feeding subjects provided blood samples on the same days. Infant blood samples for both groups were obtained on day 14. Urine toxicological screening between 36 weeks of gestation and 30 days after the birth confirmed that subjects were not using illicit substances in the perinatal period.
Concentrations of methadone in breast milk were low (range: 21.0-462.0 ng/mL) and not related to maternal dose. There was a significant increase in methadone concentrations in breast milk over time for all 4 sampling times. Concentrations of methadone in maternal plasma were not different between groups and were unrelated to maternal dose. Concentrations of methadone in infant plasma were low (range: 2.2-8.1 ng/mL) in all samples. Infants in both groups underwent neurobehavioral assessments on days 3, 14, and 30; there were no significant effects of breastfeeding on neurobehavioral outcomes. Fewer infants in the breastfed group required pharmacotherapy for neonatal abstinence syndrome, but this was not a statistically significant finding.
Results contribute to the recommendation of breastfeeding for methadone-maintained women.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2007-1182</identifier><identifier>PMID: 18166563</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Adult ; Biological and medical sciences ; Bottle Feeding ; Breast Feeding ; Breastfeeding & lactation ; Case-Control Studies ; Cohort Studies ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Fetal Blood - chemistry ; Follow-Up Studies ; Food and nutrition ; General aspects ; Humans ; Infant, Newborn ; Infants (Newborn) ; Male ; Medical sciences ; Methadone ; Methadone - administration & dosage ; Methadone - pharmacokinetics ; Methadone maintenance ; Milk, Human - chemistry ; Neonatal Abstinence Syndrome - prevention & control ; Neonatal care ; Newborn infants ; Pediatrics ; Physiological aspects ; Postpartum Period ; Pregnancy ; Prenatal drug exposure ; Probability ; Reference Values ; Risk Assessment ; Statistics, Nonparametric ; Treatment Outcome ; Women</subject><ispartof>Pediatrics (Evanston), 2008-01, Vol.121 (1), p.106-114</ispartof><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Jan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-adc181f9f5243f4c5050bb9918fb68b99d167c6a36f7f0c4d9e834e7d1bb34633</citedby><cites>FETCH-LOGICAL-c427t-adc181f9f5243f4c5050bb9918fb68b99d167c6a36f7f0c4d9e834e7d1bb34633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19977113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18166563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jansson, Lauren M</creatorcontrib><creatorcontrib>Choo, Robin</creatorcontrib><creatorcontrib>Velez, Martha L</creatorcontrib><creatorcontrib>Harrow, Cheryl</creatorcontrib><creatorcontrib>Schroeder, Jennifer R</creatorcontrib><creatorcontrib>Shakleya, Diaa M</creatorcontrib><creatorcontrib>Huestis, Marilyn A</creatorcontrib><title>Methadone Maintenance and Breastfeeding in the Neonatal Period</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>In a sample of methadone-maintained breastfeeding women and a matched group of formula-feeding women, this study evaluated concentrations of methadone in breast milk among breastfeeding women and concentrations of methadone in maternal and infant plasma in both groups.
Eight methadone-maintained (dose: 50-105 mg/day), lactating women provided blood and breast milk specimens on days 1, 2, 3, 4, 14, and 30 after delivery, at the times of trough and peak maternal methadone levels. Paired specimens of foremilk and hindmilk were obtained at each sampling time. Eight matched formula-feeding subjects provided blood samples on the same days. Infant blood samples for both groups were obtained on day 14. Urine toxicological screening between 36 weeks of gestation and 30 days after the birth confirmed that subjects were not using illicit substances in the perinatal period.
Concentrations of methadone in breast milk were low (range: 21.0-462.0 ng/mL) and not related to maternal dose. There was a significant increase in methadone concentrations in breast milk over time for all 4 sampling times. Concentrations of methadone in maternal plasma were not different between groups and were unrelated to maternal dose. Concentrations of methadone in infant plasma were low (range: 2.2-8.1 ng/mL) in all samples. Infants in both groups underwent neurobehavioral assessments on days 3, 14, and 30; there were no significant effects of breastfeeding on neurobehavioral outcomes. Fewer infants in the breastfed group required pharmacotherapy for neonatal abstinence syndrome, but this was not a statistically significant finding.
Results contribute to the recommendation of breastfeeding for methadone-maintained women.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bottle Feeding</subject><subject>Breast Feeding</subject><subject>Breastfeeding & lactation</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Follow-Up Studies</subject><subject>Food and nutrition</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methadone</subject><subject>Methadone - administration & dosage</subject><subject>Methadone - pharmacokinetics</subject><subject>Methadone maintenance</subject><subject>Milk, Human - chemistry</subject><subject>Neonatal Abstinence Syndrome - prevention & control</subject><subject>Neonatal care</subject><subject>Newborn infants</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Prenatal drug exposure</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Treatment Outcome</subject><subject>Women</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM9vFCEYhonR2G316tFMTDzOysePGeZi0m6smrTWg54JAx-7NFNmBTbqfy-T3WSFA9_hgfflIeQN0DVIwT7s0eU1o7RvARR7RlZAB9UK1svnZEUph1ZQKi_IZc6PlFIhe_aSXICCrpMdX5GP91h2xs0Rm3sTYsFoosXGRNfcJDS5eEQX4rYJsSk7bL7hHE0xU_MdU5jdK_LCmynj69N5RX7efvqx-dLePXz-urm-a22tUlrjbI30g5dMcC-spJKO4zCA8mOn6uCg621neOd7T61wAyousHcwjlx0nF-Rd8d392n-dcBc9ON8SLFGasYUVwpgqFB7hLZmQh2inet__hQ7TxNuUddCmwd9DT0Xsi6o_PrI2zTnnNDrfQpPJv3VQPViVy929WJXL3brhbenFofxCd0ZP-mswPsTYLI1k09VZshnbhj6HoCfk3dhu_sdEi5JwZQUbP5vBAa6btrxf-0PkOI</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Jansson, Lauren M</creator><creator>Choo, Robin</creator><creator>Velez, Martha L</creator><creator>Harrow, Cheryl</creator><creator>Schroeder, Jennifer R</creator><creator>Shakleya, Diaa M</creator><creator>Huestis, Marilyn A</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope></search><sort><creationdate>20080101</creationdate><title>Methadone Maintenance and Breastfeeding in the Neonatal Period</title><author>Jansson, Lauren M ; Choo, Robin ; Velez, Martha L ; Harrow, Cheryl ; Schroeder, Jennifer R ; Shakleya, Diaa M ; Huestis, Marilyn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-adc181f9f5243f4c5050bb9918fb68b99d167c6a36f7f0c4d9e834e7d1bb34633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bottle Feeding</topic><topic>Breast Feeding</topic><topic>Breastfeeding & lactation</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Follow-Up Studies</topic><topic>Food and nutrition</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methadone</topic><topic>Methadone - administration & dosage</topic><topic>Methadone - pharmacokinetics</topic><topic>Methadone maintenance</topic><topic>Milk, Human - chemistry</topic><topic>Neonatal Abstinence Syndrome - prevention & control</topic><topic>Neonatal care</topic><topic>Newborn infants</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Prenatal drug exposure</topic><topic>Probability</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Treatment Outcome</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansson, Lauren M</creatorcontrib><creatorcontrib>Choo, Robin</creatorcontrib><creatorcontrib>Velez, Martha L</creatorcontrib><creatorcontrib>Harrow, Cheryl</creatorcontrib><creatorcontrib>Schroeder, Jennifer R</creatorcontrib><creatorcontrib>Shakleya, Diaa M</creatorcontrib><creatorcontrib>Huestis, Marilyn A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansson, Lauren M</au><au>Choo, Robin</au><au>Velez, Martha L</au><au>Harrow, Cheryl</au><au>Schroeder, Jennifer R</au><au>Shakleya, Diaa M</au><au>Huestis, Marilyn A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methadone Maintenance and Breastfeeding in the Neonatal Period</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>121</volume><issue>1</issue><spage>106</spage><epage>114</epage><pages>106-114</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>In a sample of methadone-maintained breastfeeding women and a matched group of formula-feeding women, this study evaluated concentrations of methadone in breast milk among breastfeeding women and concentrations of methadone in maternal and infant plasma in both groups.
Eight methadone-maintained (dose: 50-105 mg/day), lactating women provided blood and breast milk specimens on days 1, 2, 3, 4, 14, and 30 after delivery, at the times of trough and peak maternal methadone levels. Paired specimens of foremilk and hindmilk were obtained at each sampling time. Eight matched formula-feeding subjects provided blood samples on the same days. Infant blood samples for both groups were obtained on day 14. Urine toxicological screening between 36 weeks of gestation and 30 days after the birth confirmed that subjects were not using illicit substances in the perinatal period.
Concentrations of methadone in breast milk were low (range: 21.0-462.0 ng/mL) and not related to maternal dose. There was a significant increase in methadone concentrations in breast milk over time for all 4 sampling times. Concentrations of methadone in maternal plasma were not different between groups and were unrelated to maternal dose. Concentrations of methadone in infant plasma were low (range: 2.2-8.1 ng/mL) in all samples. Infants in both groups underwent neurobehavioral assessments on days 3, 14, and 30; there were no significant effects of breastfeeding on neurobehavioral outcomes. Fewer infants in the breastfed group required pharmacotherapy for neonatal abstinence syndrome, but this was not a statistically significant finding.
Results contribute to the recommendation of breastfeeding for methadone-maintained women.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>18166563</pmid><doi>10.1542/peds.2007-1182</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological and medical sciences Bottle Feeding Breast Feeding Breastfeeding & lactation Case-Control Studies Cohort Studies Dose-Response Relationship, Drug Drug Administration Schedule Female Fetal Blood - chemistry Follow-Up Studies Food and nutrition General aspects Humans Infant, Newborn Infants (Newborn) Male Medical sciences Methadone Methadone - administration & dosage Methadone - pharmacokinetics Methadone maintenance Milk, Human - chemistry Neonatal Abstinence Syndrome - prevention & control Neonatal care Newborn infants Pediatrics Physiological aspects Postpartum Period Pregnancy Prenatal drug exposure Probability Reference Values Risk Assessment Statistics, Nonparametric Treatment Outcome Women |
| title | Methadone Maintenance and Breastfeeding in the Neonatal Period |
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