A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning
Lead (Pb) poisoning remains a common disease among children despite successful public health efforts that have reduced its prevalence. Treatment options for children with blood Pb levels (BPbs)
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| Veröffentlicht in: | Pediatrics (Evanston) 2004-01, Vol.113 (1), p.e34-e39 |
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| container_title | Pediatrics (Evanston) |
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| creator | Markowitz, Morri E Sinnett, Mark Rosen, John F |
| description | Lead (Pb) poisoning remains a common disease among children despite successful public health efforts that have reduced its prevalence. Treatment options for children with blood Pb levels (BPbs) |
| doi_str_mv | 10.1542/peds.113.1.e34 |
| format | Article |
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Children aged 1 to 6 years with BPbs 10 to 45 micro g/dL were enrolled in a double-blinded, placebo-controlled trial of the effects of Ca supplementation on BPbs. Children received either a Ca-containing liquid or an indistinguishable placebo. Dosage was adjusted biweekly on the basis of responses to a dietary Ca intake questionnaire to reach 1800 mg in the Ca-supplemented group. Samples for BPbs and measures to assess safety were collected before and after 3 months of supplementation and after an additional 3 months of follow-up. Bivariate and multiple regression analyses were performed.
A total of 67 of 88 enrolled children with a mean age of 3.6 years completed 3 months of supplementation. There were no statistically significant differences between groups on hematologic and biochemical measures, including serum and urinary Ca, at any time points. The average compliance rate was estimated to be 80% for each group during the 3-month supplementation period.
At enrollment, the average daily Ca intake in this group of inner-city children was greater than the recommended daily intake for age. Although BPbs declined during a 3-month period in both groups, Ca supplementation aimed at providing 1800 mg of Ca/day had no effect on the change in BPbs. Ca supplementation should not be routinely prescribed for mild to moderately Pb-poisoned children who are dietarily Ca sufficient.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.113.1.e34</identifier><identifier>PMID: 14702492</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: Am Acad Pediatrics</publisher><subject>Calcium - therapeutic use ; Calcium, Dietary ; Child ; Child, Preschool ; Humans ; Infant ; Lead - blood ; Lead Poisoning - drug therapy ; Nutrition Policy ; Patient Selection ; Pediatrics ; Prospective Studies ; Regression Analysis ; Treatment Failure</subject><ispartof>Pediatrics (Evanston), 2004-01, Vol.113 (1), p.e34-e39</ispartof><rights>Copyright National Library of Medicine - MEDLINE Abstracts Jan 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-292b8c1500e386d48cb9533bafc2000ce797191d083e513ce911aa9b674e3063</citedby><cites>FETCH-LOGICAL-c399t-292b8c1500e386d48cb9533bafc2000ce797191d083e513ce911aa9b674e3063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14702492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markowitz, Morri E</creatorcontrib><creatorcontrib>Sinnett, Mark</creatorcontrib><creatorcontrib>Rosen, John F</creatorcontrib><title>A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Lead (Pb) poisoning remains a common disease among children despite successful public health efforts that have reduced its prevalence. Treatment options for children with blood Pb levels (BPbs) <45 micro g/dL are limited because chelation therapy is generally not indicated. Calcium (Ca) and Pb interactions are well documented. Competition for binding to Ca-binding proteins may underlie a mechanism for Pb absorption. The purpose of this study was to determine the role, if any, of supplemental Ca at reducing BPbs in moderately poisoned children.
Children aged 1 to 6 years with BPbs 10 to 45 micro g/dL were enrolled in a double-blinded, placebo-controlled trial of the effects of Ca supplementation on BPbs. Children received either a Ca-containing liquid or an indistinguishable placebo. Dosage was adjusted biweekly on the basis of responses to a dietary Ca intake questionnaire to reach 1800 mg in the Ca-supplemented group. Samples for BPbs and measures to assess safety were collected before and after 3 months of supplementation and after an additional 3 months of follow-up. Bivariate and multiple regression analyses were performed.
A total of 67 of 88 enrolled children with a mean age of 3.6 years completed 3 months of supplementation. There were no statistically significant differences between groups on hematologic and biochemical measures, including serum and urinary Ca, at any time points. The average compliance rate was estimated to be 80% for each group during the 3-month supplementation period.
At enrollment, the average daily Ca intake in this group of inner-city children was greater than the recommended daily intake for age. Although BPbs declined during a 3-month period in both groups, Ca supplementation aimed at providing 1800 mg of Ca/day had no effect on the change in BPbs. Ca supplementation should not be routinely prescribed for mild to moderately Pb-poisoned children who are dietarily Ca sufficient.</description><subject>Calcium - therapeutic use</subject><subject>Calcium, Dietary</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Infant</subject><subject>Lead - blood</subject><subject>Lead Poisoning - drug therapy</subject><subject>Nutrition Policy</subject><subject>Patient Selection</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Treatment Failure</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM9LwzAUx4Mobk6vHiV4b81L0rU5yvAnA0V3D2mSbhltU5MW0b_ejg3m6b3D9_t5jw9C10BSyDi966yJKQBLIbWMn6ApEFEknObZKZoSwiDhhGQTdBHjlhDCs5yeownwnFAu6BS93uMP1RrfuF9r8Co4VWNf4YWqtRsa_Dl0XW0b2_aqd77FlQ94sXG12Xhv8NIqg9-9i7517foSnVWqjvbqMGdo9fiwWjwny7enl8X9MtFMiD6hgpaFhowQy4q54YUuRcZYqSpNxw-1zUUOAgwpmM2AaSsAlBLlPOeWkTmbods9tgv-a7Cxl1s_hHa8KCkt2Fzwgo2hdB_SwccYbCW74BoVfiQQuRMnd-LkKE6CHMWNhZsDdSgba47xg6kjcePWm28X7I7gVB-cjv_WI_EPzKx5Rw</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Markowitz, Morri E</creator><creator>Sinnett, Mark</creator><creator>Rosen, John F</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope></search><sort><creationdate>20040101</creationdate><title>A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning</title><author>Markowitz, Morri E ; Sinnett, Mark ; Rosen, John F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-292b8c1500e386d48cb9533bafc2000ce797191d083e513ce911aa9b674e3063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Calcium - therapeutic use</topic><topic>Calcium, Dietary</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Infant</topic><topic>Lead - blood</topic><topic>Lead Poisoning - drug therapy</topic><topic>Nutrition Policy</topic><topic>Patient Selection</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markowitz, Morri E</creatorcontrib><creatorcontrib>Sinnett, Mark</creatorcontrib><creatorcontrib>Rosen, John F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markowitz, Morri E</au><au>Sinnett, Mark</au><au>Rosen, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>113</volume><issue>1</issue><spage>e34</spage><epage>e39</epage><pages>e34-e39</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Lead (Pb) poisoning remains a common disease among children despite successful public health efforts that have reduced its prevalence. Treatment options for children with blood Pb levels (BPbs) <45 micro g/dL are limited because chelation therapy is generally not indicated. Calcium (Ca) and Pb interactions are well documented. Competition for binding to Ca-binding proteins may underlie a mechanism for Pb absorption. The purpose of this study was to determine the role, if any, of supplemental Ca at reducing BPbs in moderately poisoned children.
Children aged 1 to 6 years with BPbs 10 to 45 micro g/dL were enrolled in a double-blinded, placebo-controlled trial of the effects of Ca supplementation on BPbs. Children received either a Ca-containing liquid or an indistinguishable placebo. Dosage was adjusted biweekly on the basis of responses to a dietary Ca intake questionnaire to reach 1800 mg in the Ca-supplemented group. Samples for BPbs and measures to assess safety were collected before and after 3 months of supplementation and after an additional 3 months of follow-up. Bivariate and multiple regression analyses were performed.
A total of 67 of 88 enrolled children with a mean age of 3.6 years completed 3 months of supplementation. There were no statistically significant differences between groups on hematologic and biochemical measures, including serum and urinary Ca, at any time points. The average compliance rate was estimated to be 80% for each group during the 3-month supplementation period.
At enrollment, the average daily Ca intake in this group of inner-city children was greater than the recommended daily intake for age. Although BPbs declined during a 3-month period in both groups, Ca supplementation aimed at providing 1800 mg of Ca/day had no effect on the change in BPbs. Ca supplementation should not be routinely prescribed for mild to moderately Pb-poisoned children who are dietarily Ca sufficient.</abstract><cop>United States</cop><pub>Am Acad Pediatrics</pub><pmid>14702492</pmid><doi>10.1542/peds.113.1.e34</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Calcium - therapeutic use Calcium, Dietary Child Child, Preschool Humans Infant Lead - blood Lead Poisoning - drug therapy Nutrition Policy Patient Selection Pediatrics Prospective Studies Regression Analysis Treatment Failure |
| title | A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning |
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