Polymorphisms of B7 (CD80 and CD86) Genes Do Not Affect Disease Susceptibility to Sarcoidosis
Background: B7 proteins (CD80, CD86) are costimulatory molecules expressed on antigen-presenting cells and are essential factors for T cell activation. Objectives: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of...
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| Veröffentlicht in: | Respiration 2005-05, Vol.72 (3), p.243-248 |
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| creator | Handa, Tomohiro Nagai, Sonoko Ito, Isao Tabuena, Rollin Shigematsu, Michio Hamada, Kunio Kitaichi, Masanori Izumi, Takateru Aoyama, Tomoki Toguchida, Junya Mishima, Michiaki |
| description | Background: B7 proteins (CD80, CD86) are costimulatory molecules expressed on antigen-presenting cells and are essential factors for T cell activation. Objectives: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese sarcoidosis patients. Methods: Gene polymorphisms located in CD80 promoter, CD80 exon 3 and exon 8 of CD86 were examined in 146 Japanese sarcoidosis patients and 157 healthy controls using single-strand conformation polymorphism and direct sequencing. The distribution of genotypes was compared between the two groups. BAL fluid cell profiles were compared for the various genotypes of the different polymorphisms for the 62 patients who underwent BAL. Results: There were no significant differences in the distribution of genotypes or allele frequencies for all polymorphisms between sarcoidosis and controls. There were no significant differences in BAL fluid cell profiles among the different genotype groups of the various polymorphisms studied. Conclusions: There was no relationship between the B7 gene polymorphisms studied and disease susceptibility or BAL fluid cell profiles in Japanese sarcoidosis patients. |
| doi_str_mv | 10.1159/000085364 |
| format | Article |
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Objectives: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese sarcoidosis patients. Methods: Gene polymorphisms located in CD80 promoter, CD80 exon 3 and exon 8 of CD86 were examined in 146 Japanese sarcoidosis patients and 157 healthy controls using single-strand conformation polymorphism and direct sequencing. The distribution of genotypes was compared between the two groups. BAL fluid cell profiles were compared for the various genotypes of the different polymorphisms for the 62 patients who underwent BAL. Results: There were no significant differences in the distribution of genotypes or allele frequencies for all polymorphisms between sarcoidosis and controls. There were no significant differences in BAL fluid cell profiles among the different genotype groups of the various polymorphisms studied. Conclusions: There was no relationship between the B7 gene polymorphisms studied and disease susceptibility or BAL fluid cell profiles in Japanese sarcoidosis patients.</description><identifier>ISSN: 0025-7931</identifier><identifier>EISSN: 1423-0356</identifier><identifier>DOI: 10.1159/000085364</identifier><identifier>PMID: 15942292</identifier><identifier>CODEN: RESPBD</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Antigens, CD - genetics ; B7-1 Antigen - genetics ; B7-2 Antigen ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - immunology ; Clinical Investigations ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Lymphocyte Count ; Male ; Medical sciences ; Membrane Glycoproteins - genetics ; Middle Aged ; Odds Ratio ; Pneumology ; Polymorphism, Genetic - genetics ; Sarcoidosis - genetics ; Sarcoidosis - immunology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>Respiration, 2005-05, Vol.72 (3), p.243-248</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 S. Karger AG, Basel</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-27b374f3a72e641959129c0b30ffcfd27cb1a78d7d81705adca78c8b1eb7a95e3</citedby><cites>FETCH-LOGICAL-c391t-27b374f3a72e641959129c0b30ffcfd27cb1a78d7d81705adca78c8b1eb7a95e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2427,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16820155$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15942292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handa, Tomohiro</creatorcontrib><creatorcontrib>Nagai, Sonoko</creatorcontrib><creatorcontrib>Ito, Isao</creatorcontrib><creatorcontrib>Tabuena, Rollin</creatorcontrib><creatorcontrib>Shigematsu, Michio</creatorcontrib><creatorcontrib>Hamada, Kunio</creatorcontrib><creatorcontrib>Kitaichi, Masanori</creatorcontrib><creatorcontrib>Izumi, Takateru</creatorcontrib><creatorcontrib>Aoyama, Tomoki</creatorcontrib><creatorcontrib>Toguchida, Junya</creatorcontrib><creatorcontrib>Mishima, Michiaki</creatorcontrib><title>Polymorphisms of B7 (CD80 and CD86) Genes Do Not Affect Disease Susceptibility to Sarcoidosis</title><title>Respiration</title><addtitle>Respiration</addtitle><description>Background: B7 proteins (CD80, CD86) are costimulatory molecules expressed on antigen-presenting cells and are essential factors for T cell activation. Objectives: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese sarcoidosis patients. Methods: Gene polymorphisms located in CD80 promoter, CD80 exon 3 and exon 8 of CD86 were examined in 146 Japanese sarcoidosis patients and 157 healthy controls using single-strand conformation polymorphism and direct sequencing. The distribution of genotypes was compared between the two groups. BAL fluid cell profiles were compared for the various genotypes of the different polymorphisms for the 62 patients who underwent BAL. Results: There were no significant differences in the distribution of genotypes or allele frequencies for all polymorphisms between sarcoidosis and controls. There were no significant differences in BAL fluid cell profiles among the different genotype groups of the various polymorphisms studied. Conclusions: There was no relationship between the B7 gene polymorphisms studied and disease susceptibility or BAL fluid cell profiles in Japanese sarcoidosis patients.</description><subject>Antigens, CD - genetics</subject><subject>B7-1 Antigen - genetics</subject><subject>B7-2 Antigen</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Clinical Investigations</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Sarcoidosis - genetics</subject><subject>Sarcoidosis - immunology</subject><subject>Sarcoidosis. 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Objectives: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese sarcoidosis patients. Methods: Gene polymorphisms located in CD80 promoter, CD80 exon 3 and exon 8 of CD86 were examined in 146 Japanese sarcoidosis patients and 157 healthy controls using single-strand conformation polymorphism and direct sequencing. The distribution of genotypes was compared between the two groups. BAL fluid cell profiles were compared for the various genotypes of the different polymorphisms for the 62 patients who underwent BAL. Results: There were no significant differences in the distribution of genotypes or allele frequencies for all polymorphisms between sarcoidosis and controls. There were no significant differences in BAL fluid cell profiles among the different genotype groups of the various polymorphisms studied. Conclusions: There was no relationship between the B7 gene polymorphisms studied and disease susceptibility or BAL fluid cell profiles in Japanese sarcoidosis patients.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>15942292</pmid><doi>10.1159/000085364</doi><tpages>6</tpages></addata></record> |
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| subjects | Antigens, CD - genetics B7-1 Antigen - genetics B7-2 Antigen Biological and medical sciences Bronchoalveolar Lavage Fluid - immunology Clinical Investigations Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genotype Humans Lymphocyte Count Male Medical sciences Membrane Glycoproteins - genetics Middle Aged Odds Ratio Pneumology Polymorphism, Genetic - genetics Sarcoidosis - genetics Sarcoidosis - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Polymorphisms of B7 (CD80 and CD86) Genes Do Not Affect Disease Susceptibility to Sarcoidosis |
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