Persistent Changes in Stress‐Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol

Background We have recently shown that binge or heavy levels of alcohol drinking increase deoxyribonucleic acid (DNA) methylation and reduce gene expression of proopiomelanocortin (POMC) and period 2 (PER2) in adult human subjects (Gangisetty et al., Alcohol Clin Exp Res, 43, 2019, 212). One hypothe...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2019-09, Vol.43 (9), p.1887-1897
Hauptverfasser:	Sarkar, Dipak K., Gangisetty, Omkaram, Wozniak, Jeffrey R., Eckerle, Judith K., Georgieff, Michael K., Foroud, Tatiana M., Wetherill, Leah, Wertelecki, Wladimir, Chambers, Christina D., Riley, Edward, Zymak‐Zakutnya, Natalya, Yevtushok, Lyubov
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenocorticotropic hormone Adult Alcohol Alcohol use Alcohols Biological properties Biological samples Case-Control Studies Central Nervous System Depressants - adverse effects Child Child, Preschool Children Choline Choline - pharmacology Choline - therapeutic use Circadian Cortisol Deoxyribonucleic acid Dietary Supplements DNA DNA Methylation DNA Methylation - drug effects Drinking behavior Epigenesis, Genetic - drug effects Ethanol - adverse effects Exposure FASD Female Fetal Alcohol Spectrum Disorders - metabolism Fetal Alcohol Spectrum Disorders - prevention & control Gene Expression Gene Expression Regulation - drug effects Humans Hypotheses Lipotropic Agents - pharmacology Lipotropic Agents - therapeutic use Male Menopause Period 2 protein Period Circadian Proteins - metabolism Pregnancy Prenatal experience Prenatal Exposure Delayed Effects Pro-Opiomelanocortin - metabolism Proopiomelanocortin Smoking Stress Stress Axis Supplements Women Womens health
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