A Randomized, Controlled Trial of Prophylactic Granulocyte-Macrophage Colony-Stimulating Factor in Human Newborns Less Than 32 Weeks Gestation

Preterm neonates undergoing intensive care have high morbidity from sepsis. These infants also frequently develop neutropenia, and when this is associated with sepsis, mortality is high. This study investigates the potential for granulocyte-macrophage colony-stimulating factor (GM-CSF) to effect a c...

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Veröffentlicht in:	Pediatrics (Evanston) 1999-04, Vol.103 (4), p.796-802
Hauptverfasser:	Carr, Robert, Modi, Neena, Dore, Caroline J, El-Rifai, Rim, Lindo, Dwight
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial infections Biological and medical sciences Blood Cell Count Blood. Blood coagulation. Reticuloendothelial system Care and treatment Drug therapy Evaluation Female Granulocyte-macrophage colony stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Humans Infant mortality Infant, Newborn Infant, Premature - blood Infant, Premature - immunology Infant, Small for Gestational Age - blood Infant, Small for Gestational Age - immunology Infants (Newborn) Leukocyte Count - drug effects Male Medical sciences Neutropenia Neutropenia - prevention & control Neutrophils - drug effects Newborn infants Odds Ratio Pediatrics Pharmacology. Drug treatments Prevention Sepsis - mortality Sepsis - prevention & control
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