Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells
Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conj...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2019-10, Vol.107 (7), p.2281-2287 |
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| creator | Tanaka, Mai Okinaga, Toshinori Iwanaga, Kenjiro Matsuo, Kou Toyono, Takashi Sasaguri, Masaaki Ariyoshi, Wataru Tominaga, Kazuhiro Enomoto, Yasushi Matsumura, Yasufumi Nishihara, Tatsuji |
| description | Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti‐cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC‐3‐M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model. PtNCP beads were injected locally and examined by measuring tumor volume and comparing pathological histology. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo. PtNCP beads inhibited the cell viability of HSC‐3‐M3 cells in dose‐dependent manner and induced the cytotoxicity with extracellular LDH value, in vitro. Furthermore, SEM images were morphologically observed in PtNCP beads‐treated HSC‐3‐M3 cells. The aggregation of the PtNCP beads on the cell membrane, the destructions of the cell membrane and globular structures were observed in the SEM image. Our results indicated that a potential anti‐cancer effect of the PtNCP beads, suggesting the possibility as a therapeutic tool for cancer cell‐targeted therapy. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2281–2287, 2019. |
| doi_str_mv | 10.1002/jbm.b.34320 |
| format | Article |
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Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti‐cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC‐3‐M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model. PtNCP beads were injected locally and examined by measuring tumor volume and comparing pathological histology. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo. PtNCP beads inhibited the cell viability of HSC‐3‐M3 cells in dose‐dependent manner and induced the cytotoxicity with extracellular LDH value, in vitro. Furthermore, SEM images were morphologically observed in PtNCP beads‐treated HSC‐3‐M3 cells. The aggregation of the PtNCP beads on the cell membrane, the destructions of the cell membrane and globular structures were observed in the SEM image. Our results indicated that a potential anti‐cancer effect of the PtNCP beads, suggesting the possibility as a therapeutic tool for cancer cell‐targeted therapy. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2281–2287, 2019.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.34320</identifier><identifier>PMID: 30689290</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>anticancer effect ; Anticancer properties ; Beads ; Biocompatibility ; Biomedical materials ; Cancer ; Cell death ; Cell membranes ; Cell viability ; Cytotoxicity ; Histology ; Latex ; Latex beads ; Materials research ; Materials science ; Nanocomposites ; Nanoparticles ; Oral cancer ; Oral squamous cell carcinoma ; Physiochemistry ; Platinum ; platinum nanoparticles ; Scanning electron microscopy ; Squamous cell carcinoma ; Surface charge ; Toxicity ; Tumor cell lines ; Tumors ; Xenografts ; Xenotransplantation</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2019-10, Vol.107 (7), p.2281-2287</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4260-e48b95b3f1e9ba3733407ced012966e1a259dbe28cfd64b8316a0490147f83793</citedby><cites>FETCH-LOGICAL-c4260-e48b95b3f1e9ba3733407ced012966e1a259dbe28cfd64b8316a0490147f83793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.34320$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.34320$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30689290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Mai</creatorcontrib><creatorcontrib>Okinaga, Toshinori</creatorcontrib><creatorcontrib>Iwanaga, Kenjiro</creatorcontrib><creatorcontrib>Matsuo, Kou</creatorcontrib><creatorcontrib>Toyono, Takashi</creatorcontrib><creatorcontrib>Sasaguri, Masaaki</creatorcontrib><creatorcontrib>Ariyoshi, Wataru</creatorcontrib><creatorcontrib>Tominaga, Kazuhiro</creatorcontrib><creatorcontrib>Enomoto, Yasushi</creatorcontrib><creatorcontrib>Matsumura, Yasufumi</creatorcontrib><creatorcontrib>Nishihara, Tatsuji</creatorcontrib><title>Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti‐cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC‐3‐M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model. PtNCP beads were injected locally and examined by measuring tumor volume and comparing pathological histology. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo. PtNCP beads inhibited the cell viability of HSC‐3‐M3 cells in dose‐dependent manner and induced the cytotoxicity with extracellular LDH value, in vitro. Furthermore, SEM images were morphologically observed in PtNCP beads‐treated HSC‐3‐M3 cells. The aggregation of the PtNCP beads on the cell membrane, the destructions of the cell membrane and globular structures were observed in the SEM image. Our results indicated that a potential anti‐cancer effect of the PtNCP beads, suggesting the possibility as a therapeutic tool for cancer cell‐targeted therapy. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2281–2287, 2019.</description><subject>anticancer effect</subject><subject>Anticancer properties</subject><subject>Beads</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell membranes</subject><subject>Cell viability</subject><subject>Cytotoxicity</subject><subject>Histology</subject><subject>Latex</subject><subject>Latex beads</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Physiochemistry</subject><subject>Platinum</subject><subject>platinum nanoparticles</subject><subject>Scanning electron microscopy</subject><subject>Squamous cell carcinoma</subject><subject>Surface charge</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Xenografts</subject><subject>Xenotransplantation</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUQIMotlZX7iXgUlrzmkeWbfFJxY0uJSSZOzBlJmmTGaV_7_Rhl65yA4dzLweha0omlBB2vzTNxEy44IycoCFNEjYWMqenxznjA3QR47KHU5LwczTgJM0lk2SIvqaurax2FgKGsgTbYl9i57-hxqtat5XrGuy089Y3Kx-rFrABXUTsHfZB1ziuO934LmILdY2tDrZyvtG7b7xEZ6WuI1wd3hH6fHz4mD-PF-9PL_PpYmxFf9IYRG5kYnhJQRrNM84FySwUhDKZpkA1S2RhgOW2LFJhck5TTYQkVGRlzjPJR-h2710Fv-4gtmrpu-D6lYqxnDNBOd9Sd3vKBh9jgFKtQtXosFGUqG1K1adURu1S9vTNwdmZBooj-9euB9ge-Klq2PznUq-zt9ne-gunsn61</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Tanaka, Mai</creator><creator>Okinaga, Toshinori</creator><creator>Iwanaga, Kenjiro</creator><creator>Matsuo, Kou</creator><creator>Toyono, Takashi</creator><creator>Sasaguri, Masaaki</creator><creator>Ariyoshi, Wataru</creator><creator>Tominaga, Kazuhiro</creator><creator>Enomoto, Yasushi</creator><creator>Matsumura, Yasufumi</creator><creator>Nishihara, Tatsuji</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>201910</creationdate><title>Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells</title><author>Tanaka, Mai ; Okinaga, Toshinori ; Iwanaga, Kenjiro ; Matsuo, Kou ; Toyono, Takashi ; Sasaguri, Masaaki ; Ariyoshi, Wataru ; Tominaga, Kazuhiro ; Enomoto, Yasushi ; Matsumura, Yasufumi ; Nishihara, Tatsuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4260-e48b95b3f1e9ba3733407ced012966e1a259dbe28cfd64b8316a0490147f83793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>anticancer effect</topic><topic>Anticancer properties</topic><topic>Beads</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Cell membranes</topic><topic>Cell viability</topic><topic>Cytotoxicity</topic><topic>Histology</topic><topic>Latex</topic><topic>Latex beads</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Physiochemistry</topic><topic>Platinum</topic><topic>platinum nanoparticles</topic><topic>Scanning electron microscopy</topic><topic>Squamous cell carcinoma</topic><topic>Surface charge</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Xenografts</topic><topic>Xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Mai</creatorcontrib><creatorcontrib>Okinaga, Toshinori</creatorcontrib><creatorcontrib>Iwanaga, Kenjiro</creatorcontrib><creatorcontrib>Matsuo, Kou</creatorcontrib><creatorcontrib>Toyono, Takashi</creatorcontrib><creatorcontrib>Sasaguri, Masaaki</creatorcontrib><creatorcontrib>Ariyoshi, Wataru</creatorcontrib><creatorcontrib>Tominaga, Kazuhiro</creatorcontrib><creatorcontrib>Enomoto, Yasushi</creatorcontrib><creatorcontrib>Matsumura, Yasufumi</creatorcontrib><creatorcontrib>Nishihara, Tatsuji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Mai</au><au>Okinaga, Toshinori</au><au>Iwanaga, Kenjiro</au><au>Matsuo, Kou</au><au>Toyono, Takashi</au><au>Sasaguri, Masaaki</au><au>Ariyoshi, Wataru</au><au>Tominaga, Kazuhiro</au><au>Enomoto, Yasushi</au><au>Matsumura, Yasufumi</au><au>Nishihara, Tatsuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2019-10</date><risdate>2019</risdate><volume>107</volume><issue>7</issue><spage>2281</spage><epage>2287</epage><pages>2281-2287</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti‐cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC‐3‐M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model. PtNCP beads were injected locally and examined by measuring tumor volume and comparing pathological histology. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo. PtNCP beads inhibited the cell viability of HSC‐3‐M3 cells in dose‐dependent manner and induced the cytotoxicity with extracellular LDH value, in vitro. Furthermore, SEM images were morphologically observed in PtNCP beads‐treated HSC‐3‐M3 cells. The aggregation of the PtNCP beads on the cell membrane, the destructions of the cell membrane and globular structures were observed in the SEM image. Our results indicated that a potential anti‐cancer effect of the PtNCP beads, suggesting the possibility as a therapeutic tool for cancer cell‐targeted therapy. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2281–2287, 2019.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30689290</pmid><doi>10.1002/jbm.b.34320</doi><tpages>7</tpages></addata></record> |
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| subjects | anticancer effect Anticancer properties Beads Biocompatibility Biomedical materials Cancer Cell death Cell membranes Cell viability Cytotoxicity Histology Latex Latex beads Materials research Materials science Nanocomposites Nanoparticles Oral cancer Oral squamous cell carcinoma Physiochemistry Platinum platinum nanoparticles Scanning electron microscopy Squamous cell carcinoma Surface charge Toxicity Tumor cell lines Tumors Xenografts Xenotransplantation |
| title | Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells |
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