Effect of the Composition of an Esterification Mixture on the Acid Properties of Gel-Forming Phosphorylated Polysaccharides
The physicochemical and biological properties of hydrogels based on starch, dextran, and cellulose phosphates synthesized in orthophosphoric acid–tributyl phosphate–phosphorus(V) oxide and orthophosphoric acid–urea systems are studied. It is found the apparent first step ionization constants of phos...
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| Veröffentlicht in: | Russian Journal of Physical Chemistry A 2019-09, Vol.93 (9), p.1809-1816 |
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| container_issue | 9 |
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| container_title | Russian Journal of Physical Chemistry A |
| container_volume | 93 |
| creator | Yurkshtovich, T. L. Golub, N. V. Solomevich, S. O. Yurkshtovich, N. K. Bychkovskii, P. M. Kosterova, R. I. Alinovskaya, V. A. |
| description | The physicochemical and biological properties of hydrogels based on starch, dextran, and cellulose phosphates synthesized in orthophosphoric acid–tributyl phosphate–phosphorus(V) oxide and orthophosphoric acid–urea systems are studied. It is found the apparent first step ionization constants of phosphate groups lie in the range of 2.5–2.9 and are virtually independent of the nature of the initial polysaccharide, the means of esterification, and the concentration of functional groups. It is concluded that the differences between the potentiometric curves of the titration of weakly acidic groups are due to the presence of polysaccharide phosphates. Carbamate groups contribute to the formation of a more cross-linked structure of hydrogels, making it difficult to ionize phosphate groups in the second stage. It is established that gel-forming phosphorylated polysaccharides exhibit antitumor activity. |
| doi_str_mv | 10.1134/S0036024419090334 |
| format | Article |
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Carbamate groups contribute to the formation of a more cross-linked structure of hydrogels, making it difficult to ionize phosphate groups in the second stage. 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It is found the apparent first step ionization constants of phosphate groups lie in the range of 2.5–2.9 and are virtually independent of the nature of the initial polysaccharide, the means of esterification, and the concentration of functional groups. It is concluded that the differences between the potentiometric curves of the titration of weakly acidic groups are due to the presence of polysaccharide phosphates. Carbamate groups contribute to the formation of a more cross-linked structure of hydrogels, making it difficult to ionize phosphate groups in the second stage. It is established that gel-forming phosphorylated polysaccharides exhibit antitumor activity.</description><subject>Anticancer properties</subject><subject>Biological properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composition effects</subject><subject>Crosslinking</subject><subject>Esterification</subject><subject>Functional groups</subject><subject>Hydrogels</subject><subject>Phosphates</subject><subject>Phosphorus pentoxide</subject><subject>Physical Chemistry</subject><subject>Physical Chemistry of Separation Processes: Chromatography</subject><subject>Polysaccharides</subject><subject>Titration</subject><issn>0036-0244</issn><issn>1531-863X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Lw0AQxRdRsFb_AG8Bz9H9ytexlLYKFQsqeAubyWyzpc3G3S1Y_OdNrOBBPM0w7_fewCPkmtFbxoS8e6ZUpJRLyQpaUCHkCRmxRLA4T8XbKRkNcjzo5-TC-w2lskfliHzOtEYIkdVRaDCa2l1nvQnGtsNJtdHMB3RGG1Dfx0fzEfYOo34d-AmYOlo526ELBv3gWeA2nlu3M-06WjXWd411h60K2IN2e_AKoFHO1OgvyZlWW49XP3NMXuezl-l9vHxaPEwnyxh4moc4YQIUCqgpiKTIQaZcKy0wEVClCpSusgRYxrjCFBOURZKAyqta1AB5pXIxJjfH3M7Z9z36UG7s3rX9y5LznGdFJkXRU-xIgbPeO9Rl58xOuUPJaDl0XP7puPfwo8f3bLtG95v8v-kLVtaAeA</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Yurkshtovich, T. 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O.</creatorcontrib><creatorcontrib>Yurkshtovich, N. K.</creatorcontrib><creatorcontrib>Bychkovskii, P. M.</creatorcontrib><creatorcontrib>Kosterova, R. I.</creatorcontrib><creatorcontrib>Alinovskaya, V. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian Journal of Physical Chemistry A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yurkshtovich, T. L.</au><au>Golub, N. V.</au><au>Solomevich, S. O.</au><au>Yurkshtovich, N. K.</au><au>Bychkovskii, P. M.</au><au>Kosterova, R. I.</au><au>Alinovskaya, V. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Composition of an Esterification Mixture on the Acid Properties of Gel-Forming Phosphorylated Polysaccharides</atitle><jtitle>Russian Journal of Physical Chemistry A</jtitle><stitle>Russ. J. Phys. Chem</stitle><date>2019-09-01</date><risdate>2019</risdate><volume>93</volume><issue>9</issue><spage>1809</spage><epage>1816</epage><pages>1809-1816</pages><issn>0036-0244</issn><eissn>1531-863X</eissn><abstract>The physicochemical and biological properties of hydrogels based on starch, dextran, and cellulose phosphates synthesized in orthophosphoric acid–tributyl phosphate–phosphorus(V) oxide and orthophosphoric acid–urea systems are studied. It is found the apparent first step ionization constants of phosphate groups lie in the range of 2.5–2.9 and are virtually independent of the nature of the initial polysaccharide, the means of esterification, and the concentration of functional groups. It is concluded that the differences between the potentiometric curves of the titration of weakly acidic groups are due to the presence of polysaccharide phosphates. Carbamate groups contribute to the formation of a more cross-linked structure of hydrogels, making it difficult to ionize phosphate groups in the second stage. It is established that gel-forming phosphorylated polysaccharides exhibit antitumor activity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0036024419090334</doi><tpages>8</tpages></addata></record> |
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| subjects | Anticancer properties Biological properties Chemistry Chemistry and Materials Science Composition effects Crosslinking Esterification Functional groups Hydrogels Phosphates Phosphorus pentoxide Physical Chemistry Physical Chemistry of Separation Processes: Chromatography Polysaccharides Titration |
| title | Effect of the Composition of an Esterification Mixture on the Acid Properties of Gel-Forming Phosphorylated Polysaccharides |
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