Effect of NUDT15 on incidence of neutropenia in children with acute lymphoblastic leukemia

Background 6‐Mercaptopurine (6‐MP) is considered the backbone of therapy in the maintenance phase of acute lymphoblastic leukemia (ALL). Gene polymorphisms involved in thiopurine degradation are predictors of toxicity in patients treated with 6‐MP. We investigated the effects of nucleoside diphospha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pediatrics international 2019-08, Vol.61 (8), p.754-758
Hauptverfasser:	Buaboonnam, Jassada, Sripatanatadasakul, Pariwan, Treesucon, Ajjima, Glomglao, Waraporn, Siraprapapat, Preeyanun, Narkbunnam, Nattee, Vathana, Nassawee, Takpradit, Chayamon, Phuakpet, Kamon, Pongtanakul, Bunchoo, Tongsai, Sasima, Sinlapamongkolkul, Phakatip, Sanpakit, Kleebsabai
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Mercaptopurine Acute lymphoblastic leukemia Adolescent Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - therapeutic use Child Child, Preschool Children dose adjustment Dose-Response Relationship, Drug Drug Dosage Calculations Female Genetic Markers Genetic screening Heterozygote Homozygote Humans Incidence Infant Leukemia Lymphatic leukemia Maintenance Chemotherapy Male Mercaptopurine - adverse effects Mercaptopurine - metabolism Mercaptopurine - therapeutic use Neutropenia Neutropenia - chemically induced Neutropenia - epidemiology Neutropenia - genetics NUDT15 polymorphism NUDT15c.415C>T Pediatrics Polymorphism Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Pyrophosphatases - genetics Retrospective Studies Survival Survival Analysis Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!