Flower-like curcumin-loaded folic acid-conjugated ZnO-MPA- βcyclodextrin nanostructures enhanced anticancer activity and cellular uptake of curcumin in breast cancer cells

Non-spherical structures are beneficial to advance drug delivery effectiveness compared with common spherical ones, due to increased drug loading capability, improved bonding to a vascular wall, enhanced cellular uptake efficacy and prolonged circulation times. In this study, flower-like Zinc oxide-...

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Veröffentlicht in:	Materials Science & Engineering C 2019-10, Vol.103, p.109827, Article 109827
Hauptverfasser:	Ghaffari, Seyed-Behnam, Sarrafzadeh, Mohammad-Hossein, Fakhroueian, Zahra, Khorramizadeh, M.Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Mercaptopropionic Acid - chemistry 3-Mercaptopropionic Acid - pharmacology Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Antitumor agents Apoptosis Apoptosis - drug effects beta-Cyclodextrins - chemistry beta-Cyclodextrins - pharmacology Bioavailability Biotechnology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - microbiology Breast Neoplasms - pathology Cell Line, Tumor Cellular structure Conjugation Controlled release Curcumin Curcumin - chemistry Curcumin - pharmacology Cytotoxicity Drug Carriers - chemistry Drug Carriers - pharmacology Drug delivery Drug delivery systems E coli Escherichia coli - growth & development Escherichia coli Infections - drug therapy Escherichia coli Infections - metabolism Escherichia coli Infections - pathology Female Folic acid Folic Acid - pharmacology Folic acid receptor targeting Functional groups HEK293 Cells Humans Hydrophobicity Materials science Mathematical models Minimum inhibitory concentration Nanostructure Nanostructures - chemistry Nanostructures - therapeutic use Non-spherical drug delivery systems Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Staphylococcal Infections - pathology Staphylococcus aureus - growth & development Sustained release Zinc Zinc oxide Zinc Oxide - chemistry Zinc Oxide - pharmacology Zinc oxide nanostructures Zinc oxides
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