SUPPRESSION OF BLOOD COAGULATION BY NITRIC OXIDE GAS ADDED TO THE SWEEP GAS DURING VENO-VENOUS EXTRACORPOREAL MEMBRANE OXYGENATION

Clot formation in the membrane oxygenator is a serious complication in long-term extracorporeal membrane oxygenation (ECMO). In the blood vessels, nitric oxide (NO) generated by nitric oxide synthase on the endothelial cells suppresses both aggregation/activation of platelets and adhesion/activation...

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Veröffentlicht in:	International journal of artificial organs 2019-08, Vol.42 (8)
Hauptverfasser:	Kobayashi, K, Tateno, N, Yoshida, Y, Morishima, S, Kokubo, K, Kobayshi, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Blood circulation Blood coagulation Blood pressure Blood vessels Carbon dioxide Cell activation Clotting Coagulation Drug delivery systems Endothelial cells Femur Hemoglobin Heparin Inlet pressure Jugular vein L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Leukocytes Membranes Methemoglobin Nitric oxide Nitric-oxide synthase Oxygenation Platelets Respiratory therapy Surgical apparatus & instruments Veins
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