Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non‐renal Clearable Nanocarriers

Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head‐to‐head comparison between 5 nm renal clearable and 30 nm non‐renal clearable gold nanoparticle (AuNP)‐based drug delivery systems (DDSs) in the de...

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Veröffentlicht in:Angewandte Chemie International Edition 2019-08, Vol.58 (35), p.12076-12080
Hauptverfasser: Peng, Chuanqi, Yu, Mengxiao, Hsieh, Jer‐Tsong, Kapur, Payal, Zheng, Jie
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container_end_page 12080
container_issue 35
container_start_page 12076
container_title Angewandte Chemie International Edition
container_volume 58
creator Peng, Chuanqi
Yu, Mengxiao
Hsieh, Jer‐Tsong
Kapur, Payal
Zheng, Jie
description Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head‐to‐head comparison between 5 nm renal clearable and 30 nm non‐renal clearable gold nanoparticle (AuNP)‐based drug delivery systems (DDSs) in the delivery of doxorubicin (DOX). While the two DDSs themselves had comparable tumor targeting, we found their different vascular permeability played an even more important role than blood retention in the delivery and intratumoral transport of DOX, of which tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 10‐fold, respectively, for the 5 nm DDS over 30 nm one. These findings indicate that ultrahigh vascular permeability of renal clearable nanocarriers can be utilized to further improve anticancer drug delivery without the need for prolonged blood retention. Cleared for takeoff: The ultrahigh vascular permeability of renal clearable gold nanoparticles can be utilized to enhance drug delivery, intratumoral transport, and therapeutic efficacy without the need for long blood retention.
doi_str_mv 10.1002/anie.201905738
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subjects Blood
Cancer
Doxorubicin
Drug delivery
Drug delivery systems
Gold
gold nanoparticles
intratumoral transport
Kidneys
Nanoparticles
Permeability
Retention
therapeutic index
Tumors
vascular permeability
title Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non‐renal Clearable Nanocarriers
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