Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component 1 , the principles that define whether nutrition may be used to influence outcomes of cancer are unclear 2 . Ne...

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Veröffentlicht in:	Nature (London) 2019-08, Vol.572 (7769), p.397-401
Hauptverfasser:	Gao, Xia, Sanderson, Sydney M., Dai, Ziwei, Reid, Michael A., Cooper, Daniel E., Lu, Min, Richie, John P., Ciccarella, Amy, Calcagnotto, Ana, Mikhael, Peter G., Mentch, Samantha J., Liu, Juan, Ables, Gene, Kirsch, David G., Hsu, David S., Nichenametla, Sailendra N., Locasale, Jason W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 631/553 631/67/2327 64 64/60 Aging Amino acids Analysis Animal models Animals Cancer Cancer therapies Carbon Care and treatment Cell cycle Cell Line, Tumor Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Diet Dietary restrictions Disease Models, Animal Feasibility studies Female Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene expression Genes, p53 Genes, ras Healthy Volunteers Humanities and Social Sciences Humans Influence Intervention Letter Liver Male Metabolic conjugation Metabolic pathways Metabolism Metabolites Metabolomics Metastasis Methionine Methionine - administration & dosage Methionine - metabolism Methionine - pharmacology Mice Middle Aged multidisciplinary Mutation Nucleotides Nutrition Nutrition research p53 Protein Plasma Proof of Concept Study Radiation Radiation tolerance Sarcoma Sarcoma - drug therapy Sarcoma - genetics Sarcoma - metabolism Science Science (multidisciplinary) Soft Tissue Neoplasms - drug therapy Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - metabolism Sulfur Sulfur - metabolism Treatment Outcome Tumors Xenografts Xenotransplantation
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