Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients
To identify predictive assays for radiation-induced toxicity in prostate cancer patients. Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected...
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| Veröffentlicht in: | Future oncology (London, England) England), 2016-03, Vol.12 (5), p.617-624 |
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| creator | Pinkawa, Michael Brzozowska, Kinga Kriehuber, Ralf Eble, Michael J Schmitz, Sabine |
| description | To identify predictive assays for radiation-induced toxicity in prostate cancer patients.
Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.
A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI: 1.02-2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01-1.24]; p = 0.04) and late apoptotic and necrotic (HR: 1.10 [95% CI: 0.99-1.23]; p = 0.08) lymphocytes 24 h post-irradiation were found in patients with a bowel bother score decrease greater than 20 points more than 1 year after treatment.
Chromatid aberration and apoptosis/necrosis assays appear to be suitable for the prediction of radiation-induced toxicity. |
| doi_str_mv | 10.2217/fon.15.334 |
| format | Article |
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Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.
A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI: 1.02-2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01-1.24]; p = 0.04) and late apoptotic and necrotic (HR: 1.10 [95% CI: 0.99-1.23]; p = 0.08) lymphocytes 24 h post-irradiation were found in patients with a bowel bother score decrease greater than 20 points more than 1 year after treatment.
Chromatid aberration and apoptosis/necrosis assays appear to be suitable for the prediction of radiation-induced toxicity.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon.15.334</identifier><identifier>PMID: 26806671</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Aged ; Aged, 80 and over ; Apoptosis ; Apoptosis - genetics ; Apoptosis - radiation effects ; Ataxia ; Breast cancer ; Cancer therapies ; Case-Control Studies ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA Damage - radiation effects ; Gene expression ; Humans ; Laryngeal cancer ; Lymphocytes ; Lymphocytes - metabolism ; Lymphocytes - radiation effects ; Male ; Middle Aged ; Patients ; Prognosis ; Prostate cancer ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - radiotherapy ; Questionnaires ; Radiation Injuries - diagnosis ; Radiation Injuries - epidemiology ; Radiation Injuries - genetics ; Radiation therapy ; Radiation Tolerance - genetics ; Radiotherapy - adverse effects ; Radiotherapy - methods ; Radiotherapy Dosage ; Radiotherapy, Conformal - adverse effects ; Radiotherapy, Conformal - methods ; Statistical analysis ; Surveys and Questionnaires</subject><ispartof>Future oncology (London, England), 2016-03, Vol.12 (5), p.617-624</ispartof><rights>Copyright Future Medicine Ltd Mar 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-ed1966c35ed6e1d1fcb74668ff70c9875e86774fba1595ec37e49116b19f8d4c3</citedby><cites>FETCH-LOGICAL-c315t-ed1966c35ed6e1d1fcb74668ff70c9875e86774fba1595ec37e49116b19f8d4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26806671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinkawa, Michael</creatorcontrib><creatorcontrib>Brzozowska, Kinga</creatorcontrib><creatorcontrib>Kriehuber, Ralf</creatorcontrib><creatorcontrib>Eble, Michael J</creatorcontrib><creatorcontrib>Schmitz, Sabine</creatorcontrib><title>Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>To identify predictive assays for radiation-induced toxicity in prostate cancer patients.
Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.
A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI: 1.02-2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01-1.24]; p = 0.04) and late apoptotic and necrotic (HR: 1.10 [95% CI: 0.99-1.23]; p = 0.08) lymphocytes 24 h post-irradiation were found in patients with a bowel bother score decrease greater than 20 points more than 1 year after treatment.
Chromatid aberration and apoptosis/necrosis assays appear to be suitable for the prediction of radiation-induced toxicity.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis - radiation effects</subject><subject>Ataxia</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - radiation effects</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - radiation effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Questionnaires</subject><subject>Radiation Injuries - diagnosis</subject><subject>Radiation Injuries - epidemiology</subject><subject>Radiation Injuries - genetics</subject><subject>Radiation therapy</subject><subject>Radiation Tolerance - genetics</subject><subject>Radiotherapy - adverse effects</subject><subject>Radiotherapy - methods</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Statistical analysis</subject><subject>Surveys and Questionnaires</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kF1LwzAUhoMobk5v_AFS8E7o7Gm-2ksZfsFAL_S6tMkJZmxNTbJh_72ZTq9ODnny5uUh5BKKeVmCvDWunwOfU8qOyBQkY3lFCzhOZybrXIiaTchZCKuiYJLy4pRMSlEVQkiYkuHVo7YqWtdnzmS-1bbdL7nt9VahzqL7ssrGMevGzPbZzkbvfjAXsA822t3-Mj1dj5vhw6kxYtiDg3chthEz1fYKfTakWOxjOCcnpl0HvDjMGXl_uH9bPOXLl8fnxd0yVxR4zFFDLYSiHLVA0GBUJ5kQlTGyUHUlOVZCSma6FnjNUVGJrAYQHdSm0kzRGbn-zU1FPrcYYrNyW9-nL5uylByqpEIk6uaXUqlu8GiawdtN68cGimYvt0lyG-BNkpvgq0Pkttug_kf_bNJvqgt3ng</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Pinkawa, Michael</creator><creator>Brzozowska, Kinga</creator><creator>Kriehuber, Ralf</creator><creator>Eble, Michael J</creator><creator>Schmitz, Sabine</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160301</creationdate><title>Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients</title><author>Pinkawa, Michael ; Brzozowska, Kinga ; Kriehuber, Ralf ; Eble, Michael J ; Schmitz, Sabine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-ed1966c35ed6e1d1fcb74668ff70c9875e86774fba1595ec37e49116b19f8d4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Apoptosis - radiation effects</topic><topic>Ataxia</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Case-Control Studies</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - radiation effects</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Laryngeal cancer</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - radiation effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Questionnaires</topic><topic>Radiation Injuries - diagnosis</topic><topic>Radiation Injuries - epidemiology</topic><topic>Radiation Injuries - genetics</topic><topic>Radiation therapy</topic><topic>Radiation Tolerance - genetics</topic><topic>Radiotherapy - adverse effects</topic><topic>Radiotherapy - methods</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Statistical analysis</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinkawa, Michael</creatorcontrib><creatorcontrib>Brzozowska, Kinga</creatorcontrib><creatorcontrib>Kriehuber, Ralf</creatorcontrib><creatorcontrib>Eble, Michael J</creatorcontrib><creatorcontrib>Schmitz, Sabine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinkawa, Michael</au><au>Brzozowska, Kinga</au><au>Kriehuber, Ralf</au><au>Eble, Michael J</au><au>Schmitz, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>12</volume><issue>5</issue><spage>617</spage><epage>624</epage><pages>617-624</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>To identify predictive assays for radiation-induced toxicity in prostate cancer patients.
Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.
A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI: 1.02-2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01-1.24]; p = 0.04) and late apoptotic and necrotic (HR: 1.10 [95% CI: 0.99-1.23]; p = 0.08) lymphocytes 24 h post-irradiation were found in patients with a bowel bother score decrease greater than 20 points more than 1 year after treatment.
Chromatid aberration and apoptosis/necrosis assays appear to be suitable for the prediction of radiation-induced toxicity.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26806671</pmid><doi>10.2217/fon.15.334</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Apoptosis Apoptosis - genetics Apoptosis - radiation effects Ataxia Breast cancer Cancer therapies Case-Control Studies Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects Gene expression Humans Laryngeal cancer Lymphocytes Lymphocytes - metabolism Lymphocytes - radiation effects Male Middle Aged Patients Prognosis Prostate cancer Prostatic Neoplasms - complications Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Prostatic Neoplasms - radiotherapy Questionnaires Radiation Injuries - diagnosis Radiation Injuries - epidemiology Radiation Injuries - genetics Radiation therapy Radiation Tolerance - genetics Radiotherapy - adverse effects Radiotherapy - methods Radiotherapy Dosage Radiotherapy, Conformal - adverse effects Radiotherapy, Conformal - methods Statistical analysis Surveys and Questionnaires |
| title | Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients |
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