Humidifier disinfectant and use characteristics associated with lung injury in Korea
Since around the year 2000, hundreds of people in Korea have developed humidifier disinfectant‐associated lung injury (HDLI). We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who regi...
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| Veröffentlicht in: | Indoor air 2019-09, Vol.29 (5), p.735-747 |
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| creator | Ryu, Seung‐Hun Park, Dong‐Uk Lee, Eun Park, Soyoung Lee, So‐Yeon Jung, Sungsu Hong, Sang‐Bum Park, Jihoon Hong, Soo‐Jong |
| description | Since around the year 2000, hundreds of people in Korea have developed humidifier disinfectant‐associated lung injury (HDLI). We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who registered, 38% (1st round = 214, 2nd = 73, 3rd = 166) were confirmed as HDLI patients. Children aged under eight years old made up the highest proportion of HDLI cases (N = 279, 62%), followed by pregnant women (N = 31, 7%). One hundred thirty‐three (29%) of the confirmed HDLI patients died. Fifty‐seven percent of HDLI patients (N = 259) developed HDLI after |
| doi_str_mv | 10.1111/ina.12585 |
| format | Article |
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We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who registered, 38% (1st round = 214, 2nd = 73, 3rd = 166) were confirmed as HDLI patients. Children aged under eight years old made up the highest proportion of HDLI cases (N = 279, 62%), followed by pregnant women (N = 31, 7%). One hundred thirty‐three (29%) of the confirmed HDLI patients died. Fifty‐seven percent of HDLI patients (N = 259) developed HDLI after <1 year of HD use. The number of HDLI patients who used only the Oxy Saksak HD brand was found to be 176 (39%), followed by the brands Cefu (N = 27, 6%) and Aekyung (N = 22, 5%). HD products containing only polyhexamethylene guanidine phosphate (PHMG‐P) were the most frequently used among HDLI patients (N = 234, 52%), followed by oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium (PGH) (N = 27, 6%) and a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) (N = 26, 6%). The average PHMG‐P inhalation level estimated from the patient group classified as suffering lung injury definitely associated with HD use was 145.1 μg/m3 (N = 91, SD = 395.1 μg/m3), higher than levels estimated from both the probable and possible HDLI patient groups. In conclusion, HD exposure‐related variables, including type of HD brand and estimated inhalation HD level, were associated with the risk of HDLI.</description><identifier>ISSN: 0905-6947</identifier><identifier>EISSN: 1600-0668</identifier><identifier>DOI: 10.1111/ina.12585</identifier><identifier>PMID: 31278778</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Adolescent ; Adult ; Age Distribution ; Antiseptics ; Child ; Child, Preschool ; chloromethylisothiazolinone ; Disinfectants ; Disinfectants - adverse effects ; Disinfectants - analysis ; Exposure ; Female ; Field investigations ; Field tests ; Guanidine ; Guanidines - adverse effects ; Guanidines - analysis ; Humans ; humidifier disinfectant ; Humidifiers ; Inhalation ; Inhalation Exposure - adverse effects ; Inhalation Exposure - analysis ; Injuries ; lung injury ; Lung Injury - chemically induced ; Lung Injury - epidemiology ; Lungs ; Male ; methylisothiazolinone ; Middle Aged ; oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium ; Patients ; polyhexamethylene guanidine ; Pregnancy ; Pregnant Women ; Republic of Korea - epidemiology ; Respiration ; Young Adult</subject><ispartof>Indoor air, 2019-09, Vol.29 (5), p.735-747</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-2e947448186504164cd9ce348dfda7404b275bc3d57d209a2ffc07dd92e9069c3</citedby><cites>FETCH-LOGICAL-c3885-2e947448186504164cd9ce348dfda7404b275bc3d57d209a2ffc07dd92e9069c3</cites><orcidid>0000-0002-4829-5587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fina.12585$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fina.12585$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27902,27903,45552,45553</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31278778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Seung‐Hun</creatorcontrib><creatorcontrib>Park, Dong‐Uk</creatorcontrib><creatorcontrib>Lee, Eun</creatorcontrib><creatorcontrib>Park, Soyoung</creatorcontrib><creatorcontrib>Lee, So‐Yeon</creatorcontrib><creatorcontrib>Jung, Sungsu</creatorcontrib><creatorcontrib>Hong, Sang‐Bum</creatorcontrib><creatorcontrib>Park, Jihoon</creatorcontrib><creatorcontrib>Hong, Soo‐Jong</creatorcontrib><title>Humidifier disinfectant and use characteristics associated with lung injury in Korea</title><title>Indoor air</title><addtitle>Indoor Air</addtitle><description>Since around the year 2000, hundreds of people in Korea have developed humidifier disinfectant‐associated lung injury (HDLI). We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who registered, 38% (1st round = 214, 2nd = 73, 3rd = 166) were confirmed as HDLI patients. Children aged under eight years old made up the highest proportion of HDLI cases (N = 279, 62%), followed by pregnant women (N = 31, 7%). One hundred thirty‐three (29%) of the confirmed HDLI patients died. Fifty‐seven percent of HDLI patients (N = 259) developed HDLI after <1 year of HD use. The number of HDLI patients who used only the Oxy Saksak HD brand was found to be 176 (39%), followed by the brands Cefu (N = 27, 6%) and Aekyung (N = 22, 5%). HD products containing only polyhexamethylene guanidine phosphate (PHMG‐P) were the most frequently used among HDLI patients (N = 234, 52%), followed by oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium (PGH) (N = 27, 6%) and a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) (N = 26, 6%). The average PHMG‐P inhalation level estimated from the patient group classified as suffering lung injury definitely associated with HD use was 145.1 μg/m3 (N = 91, SD = 395.1 μg/m3), higher than levels estimated from both the probable and possible HDLI patient groups. In conclusion, HD exposure‐related variables, including type of HD brand and estimated inhalation HD level, were associated with the risk of HDLI.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Antiseptics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>chloromethylisothiazolinone</subject><subject>Disinfectants</subject><subject>Disinfectants - adverse effects</subject><subject>Disinfectants - analysis</subject><subject>Exposure</subject><subject>Female</subject><subject>Field investigations</subject><subject>Field tests</subject><subject>Guanidine</subject><subject>Guanidines - adverse effects</subject><subject>Guanidines - analysis</subject><subject>Humans</subject><subject>humidifier disinfectant</subject><subject>Humidifiers</subject><subject>Inhalation</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Inhalation Exposure - analysis</subject><subject>Injuries</subject><subject>lung injury</subject><subject>Lung Injury - chemically induced</subject><subject>Lung Injury - epidemiology</subject><subject>Lungs</subject><subject>Male</subject><subject>methylisothiazolinone</subject><subject>Middle Aged</subject><subject>oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium</subject><subject>Patients</subject><subject>polyhexamethylene guanidine</subject><subject>Pregnancy</subject><subject>Pregnant Women</subject><subject>Republic of Korea - epidemiology</subject><subject>Respiration</subject><subject>Young Adult</subject><issn>0905-6947</issn><issn>1600-0668</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OAjEURhujEUQXvoBp4srFQNvp75IQFSLRDa6b0nakBGawnQnh7a2C7rybb3PuuTcfALcYDXGeUajNEBMm2RnoY45QgTiX56CPFGIFV1T0wFVKa4SwKFV5CXolJkIKIftgMe22wYUq-AhdSKGuvG1N3UJTO9glD-3KRGNbH0Nqg03QpNTYYFrv4D60K7jp6g8Y6nUXDzngSxO9uQYXldkkf3PKAXh_elxMpsX87Xk2Gc8LW0rJCuLza5RKLDlDFHNqnbK-pNJVzgiK6JIItrSlY8IRpAypKouEcyovIq5sOQD3R-8uNp-dT61eN12s80lNiKCKSyZwph6OlI1NStFXehfD1sSDxkh_96dzf_qnv8zenYzdcuvdH_lbWAZGR2AfNv7wv0nPXsdH5RdpHXmf</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Ryu, Seung‐Hun</creator><creator>Park, Dong‐Uk</creator><creator>Lee, Eun</creator><creator>Park, Soyoung</creator><creator>Lee, So‐Yeon</creator><creator>Jung, Sungsu</creator><creator>Hong, Sang‐Bum</creator><creator>Park, Jihoon</creator><creator>Hong, Soo‐Jong</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-4829-5587</orcidid></search><sort><creationdate>201909</creationdate><title>Humidifier disinfectant and use characteristics associated with lung injury in Korea</title><author>Ryu, Seung‐Hun ; Park, Dong‐Uk ; Lee, Eun ; Park, Soyoung ; Lee, So‐Yeon ; Jung, Sungsu ; Hong, Sang‐Bum ; Park, Jihoon ; Hong, Soo‐Jong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-2e947448186504164cd9ce348dfda7404b275bc3d57d209a2ffc07dd92e9069c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Antiseptics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>chloromethylisothiazolinone</topic><topic>Disinfectants</topic><topic>Disinfectants - adverse effects</topic><topic>Disinfectants - analysis</topic><topic>Exposure</topic><topic>Female</topic><topic>Field investigations</topic><topic>Field tests</topic><topic>Guanidine</topic><topic>Guanidines - adverse effects</topic><topic>Guanidines - analysis</topic><topic>Humans</topic><topic>humidifier disinfectant</topic><topic>Humidifiers</topic><topic>Inhalation</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Inhalation Exposure - analysis</topic><topic>Injuries</topic><topic>lung injury</topic><topic>Lung Injury - chemically induced</topic><topic>Lung Injury - epidemiology</topic><topic>Lungs</topic><topic>Male</topic><topic>methylisothiazolinone</topic><topic>Middle Aged</topic><topic>oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium</topic><topic>Patients</topic><topic>polyhexamethylene guanidine</topic><topic>Pregnancy</topic><topic>Pregnant Women</topic><topic>Republic of Korea - epidemiology</topic><topic>Respiration</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Seung‐Hun</creatorcontrib><creatorcontrib>Park, Dong‐Uk</creatorcontrib><creatorcontrib>Lee, Eun</creatorcontrib><creatorcontrib>Park, Soyoung</creatorcontrib><creatorcontrib>Lee, So‐Yeon</creatorcontrib><creatorcontrib>Jung, Sungsu</creatorcontrib><creatorcontrib>Hong, Sang‐Bum</creatorcontrib><creatorcontrib>Park, Jihoon</creatorcontrib><creatorcontrib>Hong, Soo‐Jong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Indoor air</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryu, Seung‐Hun</au><au>Park, Dong‐Uk</au><au>Lee, Eun</au><au>Park, Soyoung</au><au>Lee, So‐Yeon</au><au>Jung, Sungsu</au><au>Hong, Sang‐Bum</au><au>Park, Jihoon</au><au>Hong, Soo‐Jong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humidifier disinfectant and use characteristics associated with lung injury in Korea</atitle><jtitle>Indoor air</jtitle><addtitle>Indoor Air</addtitle><date>2019-09</date><risdate>2019</risdate><volume>29</volume><issue>5</issue><spage>735</spage><epage>747</epage><pages>735-747</pages><issn>0905-6947</issn><eissn>1600-0668</eissn><abstract>Since around the year 2000, hundreds of people in Korea have developed humidifier disinfectant‐associated lung injury (HDLI). We collected all HD exposure‐related information from the field investigations into the locations in which the 1199 registered patients had used HD. Among the people who registered, 38% (1st round = 214, 2nd = 73, 3rd = 166) were confirmed as HDLI patients. Children aged under eight years old made up the highest proportion of HDLI cases (N = 279, 62%), followed by pregnant women (N = 31, 7%). One hundred thirty‐three (29%) of the confirmed HDLI patients died. Fifty‐seven percent of HDLI patients (N = 259) developed HDLI after <1 year of HD use. The number of HDLI patients who used only the Oxy Saksak HD brand was found to be 176 (39%), followed by the brands Cefu (N = 27, 6%) and Aekyung (N = 22, 5%). HD products containing only polyhexamethylene guanidine phosphate (PHMG‐P) were the most frequently used among HDLI patients (N = 234, 52%), followed by oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium (PGH) (N = 27, 6%) and a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) (N = 26, 6%). The average PHMG‐P inhalation level estimated from the patient group classified as suffering lung injury definitely associated with HD use was 145.1 μg/m3 (N = 91, SD = 395.1 μg/m3), higher than levels estimated from both the probable and possible HDLI patient groups. In conclusion, HD exposure‐related variables, including type of HD brand and estimated inhalation HD level, were associated with the risk of HDLI.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>31278778</pmid><doi>10.1111/ina.12585</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4829-5587</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Distribution Antiseptics Child Child, Preschool chloromethylisothiazolinone Disinfectants Disinfectants - adverse effects Disinfectants - analysis Exposure Female Field investigations Field tests Guanidine Guanidines - adverse effects Guanidines - analysis Humans humidifier disinfectant Humidifiers Inhalation Inhalation Exposure - adverse effects Inhalation Exposure - analysis Injuries lung injury Lung Injury - chemically induced Lung Injury - epidemiology Lungs Male methylisothiazolinone Middle Aged oligo (2‐(2‐ethoxy)ethoxyethyl) guanidinium Patients polyhexamethylene guanidine Pregnancy Pregnant Women Republic of Korea - epidemiology Respiration Young Adult |
| title | Humidifier disinfectant and use characteristics associated with lung injury in Korea |
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