Limited cardiotoxicity after extensive thoracic surgery and intraoperative hyperthermic intrathoracic chemotherapy with doxorubicin and cisplatin

Recently, pleural mesothelioma has been treated by cytoreductive surgery and intraoperative hyperthermic intrathoracic chemotherapy with doxorubicin and cisplatin. The well-established cardiotoxicity of doxorubicin and distressing data from an animal study raised concern about its impact on cardiac...

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Veröffentlicht in:	Annals of surgical oncology 2007-10, Vol.14 (10), p.3019-3026
Hauptverfasser:	de Bree, Eelco, van Ruth, Serge, Schotborgh, Carl E, Baas, Paul, Zoetmulder, Frans A N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastic Combined Chemotherapy Protocols - toxicity Atrial Fibrillation - blood Atrial Fibrillation - chemically induced Cardiomyopathies - blood Cardiomyopathies - chemically induced Chemotherapy, Cancer, Regional Perfusion Cisplatin - administration & dosage Cisplatin - pharmacokinetics Cisplatin - toxicity Combined Modality Therapy Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - toxicity Echocardiography - drug effects Electrocardiography - drug effects Female Humans Hyperthermia, Induced Male Mesothelioma - blood Mesothelioma - drug therapy Mesothelioma - surgery Middle Aged Neoplasm Invasiveness Pericardiectomy Pleural Neoplasms - blood Pleural Neoplasms - drug therapy Pleural Neoplasms - surgery Stroke Volume - drug effects Thoracotomy Troponin T - blood Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - chemically induced
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